基于肽的 PROTAC：病理性蛋白的“猎手”。
Peptide-Based PROTAC: The Predator of Pathological Proteins.
机构信息
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
出版信息
Cell Chem Biol. 2020 Jun 18;27(6):637-639. doi: 10.1016/j.chembiol.2020.06.002.
Qu et al. (2020) demonstrate a peptide-induced targeted degradation of the alpha-synuclein protein, a hallmark of Parkinson's disease. Using a modular three-component design, the target-protein-specific, cell-permeable peptide disposed of alpha-synuclein via the ubiquitin-proteasome pathway rather than the standard autophagy-lysosome pathway.
屈等人（2020 年）证明了一种肽诱导的靶向降解 alpha-synuclein 蛋白的方法，该蛋白是帕金森病的一个标志。该研究使用模块化的三组分设计，通过泛素-蛋白酶体途径而不是标准的自噬溶酶体途径来处理细胞穿透肽靶向的目标蛋白 alpha-synuclein。
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