在对乙酰氨基酚毒性的生物标志物开发方面的进展。
Advances in biomarker development in acetaminophen toxicity.
机构信息
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States; Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
出版信息
Adv Clin Chem. 2020;98:35-50. doi: 10.1016/bs.acc.2020.02.002. Epub 2020 Apr 27.
Acetaminophen liver injury is the most common cause of acute liver injury in the United States and several other countries. Diagnosis of acetaminophen-induced acute liver injury in the clinic is challenging due to the lack of validated and specific biomarkers. The following chapter provides an overview of recent advances evaluating candidate biomarkers in development for acetaminophen acute liver injury. Relationships of biomarkers to mechanisms of acetaminophen toxicity and their potential role in confirming the diagnosis and/or predicting evolving toxicity are addressed.
对乙酰氨基酚肝损伤是美国和其他几个国家最常见的急性肝损伤原因。由于缺乏经过验证和特定的生物标志物，临床上诊断对乙酰氨基酚引起的急性肝损伤具有挑战性。本章概述了评估用于对乙酰氨基酚急性肝损伤的候选生物标志物的最新进展。讨论了生物标志物与对乙酰氨基酚毒性机制的关系，以及它们在确认诊断和/或预测进展性毒性方面的潜在作用。
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