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在西班牙,体外膜肺氧合常温灌注在心脏死亡器官捐献中的作用。

Role of normothermic perfusión with ECMO in donation after controlled cardiac death in Spain.

作者信息

Rubio Muñoz J J, Dominguez-Gil González B, Miñambres García E, Del Río Gallegos F, Pérez-Villares J M

机构信息

Servicio de Medicina Intensiva, Unidad de Coordinación de Trasplantes, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, España.

Organización Nacional de Trasplantes, Madrid, España.

出版信息

Med Intensiva (Engl Ed). 2020 Jun 18. doi: 10.1016/j.medin.2020.01.017.

Abstract

Spain has become one of the most active countries in donation after controlled cardiac death, using normothermic abdominal perfusion with ECMO in more than 50% of all donors - a situation contributed to by the creation of mobile teams to support hospitals lacking this technology. The donation process must be respectful of the wishes and values of the patients and their relatives, especially if there is pre mortem manipulation, and the absence of cerebral perfusion should be guaranteed. The liver is the most benefited organ by reducing biliary complications as well as the loss of grafts. In renal transplantation, the technique could contribute to reduce the incidence of delayed graft function. In addition, the procedure is compatible with surgical rapid recovery in hypothermia when there is also lung donation. The future lies in the consolidation of cardiac donation by extending normothermic perfusion to the thoracic cavity.

摘要

西班牙已成为心脏死亡后捐赠最为活跃的国家之一,超过50%的捐赠者采用体外膜肺氧合(ECMO)进行常温腹部灌注——这一情况得益于组建了移动团队来支持缺乏该技术的医院。捐赠过程必须尊重患者及其亲属的意愿和价值观,尤其是在存在生前操作的情况下,并且应确保不存在脑灌注。肝脏是受益最大的器官,可减少胆道并发症以及移植物的损失。在肾移植中,该技术有助于降低移植肾功能延迟的发生率。此外,当同时进行肺捐赠时,该程序与低温下的手术快速恢复兼容。未来在于通过将常温灌注扩展至胸腔来巩固心脏捐赠。

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