对来自沙特阿拉伯的锯鳞蝰蛇（Echis carinatus）毒液的凝血活性进行的一项研究。
An investigation of the coagulant activity of the venom of the saw-scaled viper (Echis carinatus) from Saudi Arabia.
作者信息
Kamiguti A S, Theakston R D, Tomy S C
机构信息
Haematology Laboratory, Instituto Butantan, São Paulo, Brazil.
出版信息
Ann Trop Med Parasitol. 1988 Oct;82(5):503-9. doi: 10.1080/00034983.1988.11812283.
Unlike the venom of Echis carinatus from India, Pakistan, Nigeria, Kenya, Iran and Oman, Saudi Arabian E. carinatus venom is a poor activator of prothrombin. However, it possesses similar defibrinogenating activity to the other venoms. This is because the venom from Saudi Arabian snakes contains a calcium-dependent factor X activator. It is suggested that in future studies of the coagulant activity of venoms, the determination of plasma coagulant activity should be carried out in the presence of added calcium ions. This applies particularly to those venoms which do not act on plasma or fibrinogen, but which do cause in vivo defibrinogenation.
与来自印度、巴基斯坦、尼日利亚、肯尼亚、伊朗和阿曼的锯鳞蝰毒液不同，沙特阿拉伯锯鳞蝰毒液对凝血酶原的激活作用较弱。然而，它具有与其他毒液相似的去纤维蛋白活性。这是因为来自沙特阿拉伯蛇的毒液含有一种钙依赖性因子X激活剂。建议在未来对毒液凝血活性的研究中，血浆凝血活性的测定应在添加钙离子的情况下进行。这尤其适用于那些不作用于血浆或纤维蛋白原，但能在体内引起去纤维蛋白作用的毒液。
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