[母亲饮酒与子代先天性心脏病风险之间的关联：一项Meta分析]
[Association between maternal alcohol consumption and risk of congenital heart disease in offspring: a Meta analysis].
作者信息
Li Qi, Yao Hua, Gu Guan-Jun, Ma Zhao-Hui, Wu Deng-Ke, Wu Ge, Chen Yuan-Meng, Luo Tian-Nü
机构信息
Xiangxi Center for Disease Prevention and Control, Jishou, Hunan 416000, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Jun;22(6):643-650. doi: 10.7499/j.issn.1008-8830.1912083.
OBJECTIVE
To study the association between maternal alcohol consumption and the risk of congenital heart disease (CHD) in offspring.
METHODS
PubMed, Cochrane Library, Web of Science, Google Scholar, China Biology Medicine disc, Wanfang Database, CNKI Database, and Weipu Database were searched for the articles on the association between maternal alcohol consumption and congenital heart disease in offspring. These articles were published up to November 30, 2019. A random effects model or a fixed effects model was used for the pooled analysis of the results of each study, and then the pooled effective value and its 95%CI were calculated. A subgroup analysis was performed to explore heterogeneous regulators. Funnel plots and an Egger's test were used to assess publication bias.
RESULTS
A total of 4 409 articles were searched, and 55 articles were finally included in this analysis, among which there were 6 cohort studies and 49 case-control studies. The Meta analysis showed heterogeneity across all studies (I=74%, P<0.01). The random effects model showed that maternal alcohol consumption was associated with CHD in offspring, with an OR of 1.18 (95%CI: 1.09-1.28). The Egger's test showed a certain degree of publication bias (P<0.05), and after adjustment, the pooled OR of CHD in offspring was 1.10 (95%CI: 1.01-1.21).
CONCLUSIONS
Maternal alcohol consumption may increase the risk of CHD in offspring.
目的
研究孕期母亲饮酒与子代先天性心脏病（CHD）风险之间的关联。
方法
检索PubMed、Cochrane图书馆、Web of Science、谷歌学术、中国生物医学文献数据库、万方数据库、中国知网数据库和维普数据库中关于孕期母亲饮酒与子代先天性心脏病关联的文章。检索截至2019年11月30日发表的文章。采用随机效应模型或固定效应模型对每项研究结果进行合并分析，然后计算合并效应值及其95%可信区间（CI）。进行亚组分析以探索异质性调节因素。采用漏斗图和Egger检验评估发表偏倚。
结果
共检索到4409篇文章，最终纳入本分析的有55篇文章，其中队列研究6项，病例对照研究49项。Meta分析显示所有研究间存在异质性（I=74%，P<0.01）。随机效应模型显示孕期母亲饮酒与子代患CHD有关，比值比（OR）为1.18（95%CI：1.09 - 1.28）。Egger检验显示存在一定程度的发表偏倚（P<0.05），校正后子代患CHD的合并OR为1.10（95%CI：1.01 - 1.21）。
结论
孕期母亲饮酒可能增加子代患CHD的风险。
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