Marinone Michelle, Shrestha Eliza, Thapa Anita, Tuladar Ruhee, Wakefield Dorothy B, Chuang Linus
Department of Obstetrics, Gynecology and Reproductive Biology, Danbury Hospital, Western Connecticut Health Network, CT, USA.
Department of Gynecologic Oncology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal.
Gynecol Oncol Rep. 2020 May 26;33:100589. doi: 10.1016/j.gore.2020.100589. eCollection 2020 Aug.
Intraoperative frozen section plays an important role in surgical management of ovarian masses. Many hospitals in low- and middle-income countries lack this intraoperative pathologic guidance. In this retrospective analysis, we assessed the management of 62 patients who underwent surgical treatment for ovarian masses at Bhaktapur Cancer Hospital in Nepal in light of the final histopathology results. Final histopathology found that 64.5% of the ovarian masses were malignant, 1.0% were borderline, and 30.6% were benign. 55 of the 62 total cases were considered "clinically suspicious" and 52 of the 62 cases underwent hysterectomy and staging procedures in addition to oophorectomy. There was no significant difference in the surgical management or in the postoperative complications when comparing benign, borderline, and malignant masses. Without the support of intraoperative frozen section, benign and malignant masses were treated the same way. The majority of benign cases were overtreated and were exposed to additional risks of postoperative complications. Several malignant cases were undertreated and required additional surgery to appropriately treat and stage malignant ovarian masses. Improved pathology support in Bhaktapur Cancer Hospital would result in better patient outcomes, fewer complications, and avoidance of additional staging surgeries.
术中冰冻切片在卵巢肿块的手术治疗中起着重要作用。低收入和中等收入国家的许多医院缺乏这种术中病理指导。在这项回顾性分析中,我们根据最终组织病理学结果评估了尼泊尔巴克塔普尔癌症医院62例接受卵巢肿块手术治疗患者的治疗情况。最终组织病理学检查发现,64.5%的卵巢肿块为恶性,1.0%为交界性,30.6%为良性。62例患者中有55例被认为“临床可疑”,62例中有52例除卵巢切除外还接受了子宫切除和分期手术。比较良性、交界性和恶性肿块时,手术治疗或术后并发症方面没有显著差异。在没有术中冰冻切片支持的情况下,良性和恶性肿块的治疗方式相同。大多数良性病例治疗过度,并面临术后并发症的额外风险。一些恶性病例治疗不足,需要额外手术以适当治疗和分期恶性卵巢肿块。巴克塔普尔癌症医院改善病理支持将带来更好的患者预后、更少的并发症,并避免额外的分期手术。