不同左甲状腺素剂量治疗的甲状腺功能减退症母亲所生后代的甲状腺超声体积比较：一项队列研究。
Comparison of the offspring ultrasound thyroid volume in hypothyroid mothers treated with different levothyroxine doses: A cohort study.
机构信息
Neonatal and Intensive Care Department, Institute of Mother and Child, Warsaw, Poland.
Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland.
出版信息
Adv Med Sci. 2020 Sep;65(2):332-337. doi: 10.1016/j.advms.2020.05.004. Epub 2020 Jun 21.
PURPOSE
We aimed to determine the volume of the thyroid gland in full-term neonates born to hypothyroid mothers as compared with full-term infants born to healthy mothers and to investigate the association between levothyroxine doses and the thyroid volume of neonates.
MATERIALS AND METHODS
This is single center prospective observational study of 245 full-term neonates (96 from hypothyroid and 149 from healthy mothers). Ultrasound examination in both longitudinal and transverse projections was used to calculate the thyroid volume applying the ellipsoid formula.
RESULTS
Median (interquartile range) thyroid volume of newborns from hypothyroid mothers was significantly smaller compared to the control group with regard to the total thyroid volume and the left lobe (p < 0.05). We found no statistically significant difference for the right lobe (p > 0.05) and inverse correlation between the thyroid volume and levothyroxine doses taken by mothers.
CONCLUSION
Results of the present study indicate that maternal thyroid hormone levels may interfere with the fetal hypothalamic-pituitary axis.
目的
我们旨在比较甲状腺功能减退母亲所生的足月新生儿与健康母亲所生的足月婴儿的甲状腺体积，并探讨左甲状腺素剂量与新生儿甲状腺体积之间的关系。
材料和方法
这是一项对 245 名足月新生儿（甲状腺功能减退组 96 名，健康母亲组 149 名）的单中心前瞻性观察性研究。使用超声在纵向和横向平面上测量甲状腺体积，应用椭球公式计算甲状腺体积。
结果
与对照组相比，甲状腺功能减退母亲所生新生儿的总甲状腺体积和左叶甲状腺体积明显较小（p<0.05）。对于右叶甲状腺体积，我们未发现统计学差异（p>0.05），且甲状腺体积与母亲所服用的左甲状腺素剂量之间呈负相关。
结论
本研究结果表明，母亲甲状腺激素水平可能干扰胎儿下丘脑-垂体轴。
Zotero 插件