Hu Haochang, Lin Shaoyi, Wang Shuangshuang, Chen Xiaomin
School of Medicine, Ningbo University, Ningbo, China.
Department of Cardiology, Ningbo City First Hospital, Ningbo, China.
Front Cell Dev Biol. 2020 Jun 5;8:457. doi: 10.3389/fcell.2020.00457. eCollection 2020.
Transcription factor 21 (TCF21) is specific for mesoderm and is expressed in the embryos' mesenchymal derived tissues, such as the epicardium. It plays a vital role in regulating cell differentiation and cell fate specificity through epithelial-mesenchymal transformation during cardiac development. For instance, TCF21 could promote cardiac fibroblast development and inhibit vascular smooth muscle cells (VSMCs) differentiation of epicardial cells. Recent large-scale genome-wide association studies have identified a mass of loci associated with coronary heart disease (CHD). There is mounting evidence that TCF21 polymorphism might confer genetic susceptibility to CHD. However, the molecular mechanisms of TCF21 in heart development and CHD remain fundamentally problematic. In this review, we are committed to providing a detailed introduction of the biological roles of TCF21 in epicardial fate determination and the development of CHD.
转录因子21（TCF21）对中胚层具有特异性，在胚胎的间充质衍生组织如心外膜中表达。在心脏发育过程中，它通过上皮-间充质转化在调节细胞分化和细胞命运特异性方面发挥着至关重要的作用。例如，TCF21可促进心脏成纤维细胞的发育，并抑制心外膜细胞向血管平滑肌细胞（VSMC）的分化。最近大规模的全基因组关联研究已经确定了大量与冠心病（CHD）相关的基因座。越来越多的证据表明，TCF21基因多态性可能赋予CHD遗传易感性。然而，TCF21在心脏发育和CHD中的分子机制仍然存在根本性的问题。在这篇综述中，我们致力于详细介绍TCF21在心外膜命运决定和CHD发展中的生物学作用。
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