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铁氧化状态对死后人脑定量 MRI 参数的影响。

The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain.

机构信息

UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada; Department of Neuroradiology, Medical University of Innsbruck, Austria; Department of Neurology, Medical University of Graz, Austria.

Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Austria; Diagnostic and Research Institute of Pathology, Medical University of Graz, Austria.

出版信息

Neuroimage. 2020 Oct 15;220:117080. doi: 10.1016/j.neuroimage.2020.117080. Epub 2020 Jun 23.

Abstract

A variety of Magnetic Resonance Imaging (MRI) techniques are known to be sensitive to brain iron content. In principle, iron sensitive MRI techniques are based on local magnetic field variations caused by iron particles in tissue. The purpose of this study was to investigate the sensitivity of MR relaxation and magnetization transfer parameters to changes in iron oxidation state compared to changes in iron concentration. Therefore, quantitative MRI parameters including R, R, R∗, quantitative susceptibility maps (QSM) and magnetization transfer ratio (MTR) of post mortem human brain tissue were acquired prior and after chemical iron reduction to change the iron oxidation state and chemical iron extraction to decrease the total iron concentration. All assessed parameters were shown to be sensitive to changes in iron concentration whereas only R, R∗ and QSM were also sensitive to changes in iron oxidation state. Mass spectrometry confirmed that iron accumulated in the extraction solution but not in the reduction solution. R∗ and QSM are often used as markers for iron content. Changes in these parameters do not necessarily reflect variations in iron content but may also be a result of changes in the iron's oxygenation state from ferric towards more ferrous iron or vice versa.

摘要

多种磁共振成像(MRI)技术已被证明对脑铁含量敏感。原则上,铁敏感 MRI 技术基于组织中铁颗粒引起的局部磁场变化。本研究旨在研究与铁浓度变化相比,MR 弛豫和磁化转移参数对铁氧化态变化的敏感性。因此,在化学还原以改变铁氧化态和化学提取以降低总铁浓度之前和之后,获取了包括 R、R、R*、定量磁化率图(QSM)和磁化转移比(MTR)在内的定量 MRI 参数。所有评估的参数都对铁浓度的变化敏感,而只有 R、R和 QSM 对铁氧化态的变化也敏感。质谱证实铁在提取溶液中积累,但不在还原溶液中积累。R和 QSM 通常用作铁含量的标志物。这些参数的变化不一定反映铁含量的变化,也可能是铁的氧化态从三价铁向更二价铁或反之变化的结果。

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