p53、CD44、Ki-67 和 HER-2/neu 标志物在胃癌中的表达及其与组织病理学指标的关系：一项回顾性研究。

The Expression of p53, CD44, Ki-67, and HER-2/neu Markers in Gastric Cancer and Its Association with Histopathological Indicators: A Retrospective Study.

机构信息

Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Pathology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Asian Pac J Cancer Prev. 2020 Jun 1;21(6):1607-1614. doi: 10.31557/APJCP.2020.21.6.1607.

DOI:10.31557/APJCP.2020.21.6.1607

PMID:32592354

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7568877/

Abstract

BACKGROUND AND OBJECTIVES

Gastric cancer is known as one of the most common cancers and causes of deaths. Early and proper diagnosis is one of the most important things for treatment response. Therefore, this study aimed to determine the expression of p53, CD44, Ki-67, and HER-2/neu markers in the gastric cancer and its relationship with histopathological indicators.

METHODS

This is a descriptive-analytical study, in which 60 patients with cancer who underwent gastrectomy surgery in 2011-2016 in Shohadaye Tajrish Hospital. The participants were investigated for p53, CD44, Ki-67, and HER-2/neu markers' staining plus demographic characteristics, rate of survival, and histopathological features of the tumors.

RESULTS

The mean age of the participants (44 males and 16 females) was 60.25±1.29 years. The patients' survival rate was 23.82±1.56 months on average. The tumor size was reported as 6.09±2.61 mm and the major tumor type reported was intestinal type (n=40, 66.7%). The level of expression of Ki-67 and CD44 makers was recorded as 33.75 and 24.50%, and p53 and HER-2/neu genes were positive in 25 (41.7%) and 20 (33.3%) patients, respectively. The expression of p53 and CD44 markers had no significant relationship with the demographic characteristics, rate of survival, and histopathological features of the tumor of patients (all p>0.05). The expression of p53 gene was associated with the lower rate of survival (p=0.014), while the expression of HER-2/neu was associated with higher probability of developing intestinal type of stomach adenocarcinoma (p=0.010) and ulcerative macroscopic view (p=0.034).

CONCLUSION

This study illustrated that p53 and CD44 markers did not have any diagnostic value in predicting the biological behavior of gastric cancer. In fact, incidence of p53 gene was associated with the lower rate of survival, and the expression of HER-2/neu was associated with higher probability of developing the intestinal type of stomach adenocarcinoma and ulcerative macroscopic view.

摘要

背景与目的

胃癌是最常见的癌症之一，也是死亡的主要原因之一。早期和适当的诊断是治疗反应的最重要因素之一。因此，本研究旨在确定 p53、CD44、Ki-67 和 HER-2/neu 标志物在胃癌中的表达及其与组织病理学指标的关系。

方法

这是一项描述性分析研究，纳入了 2011 年至 2016 年在 Shohadaye Tajrish 医院接受胃癌切除术的 60 名癌症患者。研究人员对 p53、CD44、Ki-67 和 HER-2/neu 标志物的染色以及人口统计学特征、生存率和肿瘤的组织病理学特征进行了调查。

结果

参与者的平均年龄（44 名男性和 16 名女性）为 60.25±1.29 岁。患者的平均生存率为 23.82±1.56 个月。肿瘤大小报告为 6.09±2.61mm，主要肿瘤类型为肠型（n=40，66.7%）。Ki-67 和 CD44 标志物的表达水平分别为 33.75%和 24.50%，p53 和 HER-2/neu 基因分别在 25 名（41.7%）和 20 名（33.3%）患者中呈阳性。p53 和 CD44 标志物的表达与患者的人口统计学特征、生存率和肿瘤的组织病理学特征均无显著关系（均 p＞0.05）。p53 基因的表达与生存率降低有关（p=0.014），而 HER-2/neu 的表达与肠型胃腺癌（p=0.010）和溃疡性大体形态（p=0.034）的发生概率增加有关。