协作性眼部结核病研究（COTS）-1：165例结核性前葡萄膜炎患者的多国综述。
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis.
作者信息
Agrawal Rupesh, Betzler Bjorn, Testi Ilaria, Mahajan Sarakshi, Agarwal Aniruddha, Gunasekeran Dinesh Visva, Raje Dhananjay, Aggarwal Kanika, Murthy Somasheila I, Westcott Mark, Chee Soon-Phaik, Mccluskey Peter, Ho Su Ling, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Carreño Ester, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Esposti Simona, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett T, Kempen John H, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali
机构信息
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
出版信息
Ocul Immunol Inflamm. 2020 Sep 30;28(sup1):17-26. doi: 10.1080/09273948.2020.1761400. Epub 2020 Jun 30.
: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers.: Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year.: One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%).: In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU.
协作性眼部结核病研究（COTS）小组试图通过对国际多个中心的结核性前葡萄膜炎（TAU）患者的治疗方案和治疗结果进行回顾性队列分析，来解决诊断的不确定性。
对2004年1月至2014年12月期间诊断为TAU且至少随访1年的患者进行多中心回顾性分析。
纳入了165例患者。107例受试者接受了抗结核治疗（ATT）（n = 107/165；64.9%），所有患者均接受了局部类固醇治疗。17例患者（n = 17/165；10.3%）出现治疗失败，接受ATT的患者（n = 13/107，12.2%）比未接受ATT的患者（n = 4/58，6.9%）更常出现治疗失败。
在这项回顾性研究中，添加ATT对TAU患者的治疗结果没有任何统计学上的显著影响。
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