Universidade de São Paulo, USP, Avenida Bandeirantes, Ribeirão Preto, SP, 3900, Brazil.
Centro de Química, Universidade do Minho, Campus de Gualtar, Braga, 4710 - 057, Portugal.
J Forensic Sci. 2020 Nov;65(6):2121-2128. doi: 10.1111/1556-4029.14494. Epub 2020 Jun 30.
The need for agile and proper identification of drugs of abuse has encouraged the scientific community to improve and to develop new methodologies. The drug lysergic acid diethylamide (LSD) is still widely used due to its hallucinogenic effects. The use of voltammetric methods to analyze narcotics has increased in recent years, and the possibility of miniaturizing the electrochemical equipment allows these methods to be applied outside the laboratory; for example, in crime scenes. In addition to portability, the search for affordable and sustainable materials for use in electroanalytical research has grown in recent decades. In this context, employing paper substrate, graphite pencil, and silver paint to construct paper-based electrodes is a great alternative. Here, a paper-based device comprising three electrodes was drawn on 300 g/m watercolor paper with 8B pencils, and its efficiency was compared to the efficiency of a commercially available screen-printed carbon electrode. Square wave voltammetry was used for LSD analysis in aqueous medium containing 0.05 mol/L LiClO . The limits of detection and quantification were 0.38 and 1.27 μmol/L, respectively. Both electrodes exhibited a similar voltammetric response, which was also confirmed during analysis of a seized LSD sample, with recovery of less than 10%. The seized samples were previously analyzed by GCMS technique, employing the full scan spectra against the software spectral library. The electrode selectivity was also tested against 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine. It was possible to differentiate these compounds from LSD, indicating that the developed paper-based device has potential application in forensic chemistry analyses.
由于其致幻作用，麦角酸二乙酰胺（LSD）仍然被广泛使用。近年来，使用伏安法分析麻醉品的方法有所增加，而电化学设备的小型化使得这些方法可以在实验室之外应用；例如，在犯罪现场。除了便携性之外，近年来，人们对用于电分析研究的经济实惠且可持续的材料的需求也在增长。在这种情况下，使用纸基板、石墨铅笔和银漆来构建基于纸张的电极是一种很好的选择。在这里，使用 8B 铅笔在 300g/m 的水彩纸上绘制了一个包含三个电极的基于纸张的设备，并将其效率与市售的丝网印刷碳电极的效率进行了比较。在含有 0.05mol/L LiClO 的水溶液中，使用方波伏安法对 LSD 进行分析。检测限和定量限分别为 0.38 和 1.27μmol/L。两个电极都表现出相似的伏安响应，这在对缴获的 LSD 样品进行分析时也得到了证实，回收率低于 10%。缴获的样品之前曾通过 GCMS 技术进行过分析，使用全扫描光谱对软件光谱库进行了分析。还对 3,4-亚甲二氧基甲基苯丙胺（MDMA）和甲基苯丙胺对电极的选择性进行了测试。可以将这些化合物与 LSD 区分开来，表明开发的基于纸张的设备具有在法医化学分析中应用的潜力。
