Effects of bepridil on calcium release from rat heart mitochondria.
作者信息
Schneider J M, Berson G, Cruz C, Younes A
机构信息
Inserm U 195, Laboratoire de Pharmacologie Médicale, Faculté de Médecine, Clermont-Ferrand, France.
出版信息
Pharmacol Res Commun. 1988 Mar;20(3):183-94. doi: 10.1016/s0031-6989(88)80039-0.
PMID:3260385
Abstract
Bepridil at concentrations above 10 microM, and at pH 7.2 stimulates calcium release from rat heart mitochondria. However this action is different from that of ClCCP, an uncoupler of oxidative phosphorylations, since it is ruthenium red insensitive. At lower concentrations bepridil may inhibit the Na-induced calcium release. The effects of bepridil depend on the pH and indicate that the protonated form of the drug is more efficient on calcium release than the basic form.
摘要
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