Medical Diagnosis Group, Athens, Greece.
Department of Endocrinology, Metabolism and Diabetes Mellitus, Nikea-Piraeus Agios Panteleimon General Hospital, Athens, Greece.
In Vivo. 2020 Jul-Aug;34(4):2101-2105. doi: 10.21873/invivo.12014.
BACKGROUND/AIM: Previous studies have shown that there may be a diversity in the ultrasonographic (US) features discriminating a malignant from a benign thyroid nodule. We determined the reliability of the specific nodule shape in combination with other US features in predicting thyroid carcinomas.
This was a retrospective single-center study investigating the association of the morphological characteristics of nodular goiters from preoperative US and color Doppler images with malignancy based on pathology.
We evaluated 254 thyroid nodules (malignant, n=131) from 205 patients. Multivariable logistic regression analysis showed that taller-than-wide shape [odds ratio (OR)=25.3, 95% confidence interval (CI)=5.4-118.9; p<0.001], microcalcifications (OR=4.9, 95% CI=2.5-9.5; p<0.001), hypoechogenicity (OR=4.5; 95% CI=2-10.3; p<0.001) and size (OR=0.93; 95% CI=0.89-0.98; p=0.002) were independently associated with thyroid nodule malignancy. Additionally, we found a strong negative correlation between size and taller-than-wide shape of a thyroid nodule (r=-0.41, p<0.001).
Among the important indicators of thyroid malignancy, taller-than-wide nodules with microcalcifications are most likely to be malignant.
背景/目的：先前的研究表明，在超声（US）特征方面，区分甲状腺良恶性结节可能存在多样性。我们确定了特定结节形状与其他 US 特征相结合在预测甲状腺癌中的可靠性。
这是一项回顾性单中心研究，调查了术前 US 和彩色多普勒图像中结节性甲状腺肿的形态特征与基于病理的恶性肿瘤之间的相关性。
我们评估了 205 例患者的 254 个甲状腺结节（恶性，n=131）。多变量逻辑回归分析显示，高宽比大于 1 的形状[比值比（OR）=25.3，95%置信区间（CI）=5.4-118.9；p<0.001]、微钙化（OR=4.9，95% CI=2.5-9.5；p<0.001）、低回声（OR=4.5；95% CI=2-10.3；p<0.001）和大小（OR=0.93；95% CI=0.89-0.98；p=0.002）与甲状腺结节恶性独立相关。此外，我们还发现甲状腺结节大小与高宽比之间存在强烈的负相关（r=-0.41，p<0.001）。
在甲状腺恶性肿瘤的重要指标中，伴有微钙化的高宽比结节更有可能是恶性的。
