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血管内治疗真菌性主动脉瘤——来自英国单一中心的 20 年经验。

Endovascular management of mycotic aortic aneurysms- A 20-year experience from a single UK centre.

机构信息

Vascular Interventional Radiology, Leeds Teaching Hospital NHS Trust, Leeds, UK.

Leeds Vascular Institute, Leeds Teaching Hospital NHS Trust, Leeds, UK.

出版信息

Clin Radiol. 2020 Sep;75(9):712.e13-712.e21. doi: 10.1016/j.crad.2020.05.019. Epub 2020 Jun 29.

Abstract

AIM

To present the authors' experience of endovascular treatment of confirmed and presumed (microbiology negative) mycotic aortic aneurysms (MAA).

MATERIALS AND METHODS

Patients undergoing endovascular aortic repair were identified retrospectively from 1998 using the radiology information system and an internally kept database until 2018. The primary aim was to assess the technical success and peri-operative morbidity and mortality. The secondary aim was to assess progression of infection, re-interventions, late mortality, and correlation to antibiotic duration pre- and post-procedure.

RESULTS

Thirty-four endovascular aortic procedures were performed for MAA, excluding aorto-enteric fistulas, inflammatory aneurysms, and infected grafts without a new aneurysm. Seventy-six percent of these were thoracic and 24% abdominal. The technical success was 100%. Additional procedures were undertaken in four patients with two requiring a further endovascular procedure. There were two inpatient aneurysm-related mortalities and no inpatient conversions to open repair. The 30-day re-admission and re-intervention rate was 0%. Blood cultures were positive in 45%. There were no secondary graft infections.

CONCLUSION

This is the largest European single-centre study. It supports endovascular management of MAA as a lower-risk alternative to open surgery with the majority of patients presenting acutely, later in life and requiring emergency management.

摘要

目的

介绍作者在确诊和疑似(微生物阴性)真菌性主动脉瘤(MAA)的血管内治疗方面的经验。

材料与方法

通过放射信息系统和内部数据库,从 1998 年开始回顾性地确定接受血管内主动脉修复的患者,直到 2018 年。主要目的是评估技术成功率和围手术期发病率和死亡率。次要目的是评估感染进展、再次干预、晚期死亡率,并与术前和术后抗生素持续时间相关。

结果

34 例 MAA 进行了 34 例血管内主动脉手术,不包括主动脉肠瘘、炎症性动脉瘤和无新发动脉瘤的感染移植物。这些患者中有 76%为胸主动脉瘤,24%为腹主动脉瘤。技术成功率为 100%。4 例患者进行了额外的手术,其中 2 例需要进一步的血管内手术。有 2 例住院与动脉瘤相关的死亡,无住院患者转为开放修复。30 天再入院和再干预率为 0%。血培养阳性率为 45%。无二次移植物感染。

结论

这是欧洲最大的单中心研究。它支持血管内治疗 MAA 作为一种较开放手术风险更低的选择,大多数患者急性发病,年龄较大,需要紧急治疗。

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