Department of Internal Medicine, Rheumatology and Immunology, medius Klinik Kirchheim, Academic Teaching Hospital University of Tübingen, Kirchheim unter Teck, Germany.
Department of Internal Medicine, Rheumatology and Immunology, medius Klinik Kirchheim, Academic Teaching Hospital University of Tübingen, Kirchheim unter Teck, Germany.
Chest. 2020 Nov;158(5):e215-e219. doi: 10.1016/j.chest.2020.06.051. Epub 2020 Jul 2.
Diffuse alveolar hemorrhage (DAH) is a severe and potentially life-threatening disease manifestation. In addition to autoimmune diseases such as antineutrophil cytoplasmic antibody-associated vasculitis and anti-glomerular basement membrane syndrome, pulmonary viral infections are known to be culprits of DAH. Health-care providers worldwide in the coronavirus disease 2019 pandemic have been confronted with an unprecedented number of viral lung infections, with great variance in symptoms and severity. Hemoptysis, the key symptom of DAH, is a rare complication. We present two cases of immunocompromised patients with rapidly developing hypoxemic respiratory failure and evidence of DAH in the context of severe acute respiratory syndrome coronavirus 2 infection.
弥漫性肺泡出血 (DAH) 是一种严重且可能危及生命的疾病表现。除了抗中性粒细胞胞质抗体相关性血管炎和抗肾小球基底膜综合征等自身免疫性疾病外，肺病毒感染也已知是 DAH 的罪魁祸首。在 2019 年冠状病毒病大流行期间，全球的医疗保健提供者面临着数量空前的病毒性肺部感染，症状和严重程度差异很大。咯血是 DAH 的关键症状，但较为罕见。我们报告了两例免疫功能低下患者的病例，他们在严重急性呼吸综合征冠状病毒 2 感染的背景下迅速出现低氧血症性呼吸衰竭和 DAH 的证据。
