Anastassiadou Maria, Brancato Alba, Carrasco Cabrera Luis, Ferreira Lucien, Greco Luna, Jarrah Samira, Kazocina Aija, Leuschner Renata, Magrans Jose Oriol, Miron Ileana, Pedersen Ragnor, Raczyk Marianna, Reich Hermine, Ruocco Silvia, Sacchi Angela, Santos Miguel, Stanek Alois, Tarazona Jose, Theobald Anne, Verani Alessia
EFSA J. 2019 May 22;17(5):e05706. doi: 10.2903/j.efsa.2019.5706. eCollection 2019 May.
According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance clethodim. To assess the occurrence of clethodim residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission and European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, MRL could not be proposed because an overall consumer risk assessment could not be finalised. Risk managers should be made aware that the genotoxic potential of the clethodim metabolite 3-chloroallyl alcohol, the aglycon of 3-chlorolallyl alcohol glucoside (M14A/M15A) could not be concluded and no toxicological reference values could be derived for this metabolite. Until a conclusion on the toxicological properties of the metabolite is reached, a decision on the residue definition for risk assessment cannot be made which is a prerequisite to perform a reliable dietary risk assessment.
根据(EC)No 396/2005号法规第12条,欧洲食品安全局(EFSA)审查了目前在欧洲层面为农药活性成分烯草酮制定的最大残留限量(MRLs)。为评估烯草酮在植物、加工产品、轮作作物和牲畜中的残留情况,EFSA考虑了在91/414/EEC指令框架下得出的结论、食品法典委员会制定的最大残留限量以及成员国报告的欧洲授权(包括支持性残留数据)。基于对现有数据的评估,由于无法完成全面的消费者风险评估,因此无法提出最大残留限量。应告知风险管理者,烯草酮代谢物3-氯烯丙醇(3-氯烯丙醇葡萄糖苷的苷元,即M14A/M15A)的遗传毒性潜力无法确定,且无法得出该代谢物的毒理学参考值。在得出该代谢物毒理学特性的结论之前,无法确定用于风险评估的残留定义,而这是进行可靠的膳食风险评估的先决条件。