内皮型一氧化氮合酶基因多态性在预测直接经皮冠状动脉介入治疗后慢血流现象中的作用。

Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention.

作者信息

Kiani Reza, Alilou Sanam, Rafatnia Shirin, Taslimi Yasaman, Habibzadeh Sima, Gharibzadeh Safoora, Firouzi Ata, Rahim Shahin, Zahedmehr Ali, Mehrvarz Farzaneh, Moghadam Ahari Mehrdad, Sadeghipour Parham

机构信息

Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Turk Kardiyol Dern Ars. 2020 Jul;48(5):472-483. doi: 10.5543/tkda.2020.53849.

DOI:10.5543/tkda.2020.53849

PMID:32633262

Abstract

OBJECTIVE

The aim of the present study was to examine the association between 2 polymorphisms of the endothelial nitric oxide (eNOS) gene (-786T>C and +894G>T) and the no-reflow/slow-flow phenomenon in post-primary percutaneous coronary intervention (PPCI) patients.

METHODS

A total of 103 post-PPCI patients were enrolled. Coronary no-reflow phenomenon was defined as a Thrombolysis in Myocardial Infarction (TIMI) flow grade 0-1 and coronary slow-flow phenomenon (CSFP) was defined as a TIMI flow grade ≤2.

RESULTS

Due to the small number of post-PPCI patients with the no-reflow phenomenon (n=4), the primary comparison was made between CSFP (n=20) and normal flow (n=83) groups. There was a greater frequency of CSFP among carriers of the -786C allele of the eNOS -786T>C polymorphism (odds ratio [OR]: 3.90; 95% confidence interval [CI]: 0.87-17.45; p=0.07). However, no such association was detected between the +894T allele of the eNOS +894G>T and CSFP (OR: 0.92; 95% CI: 0.21-3.98; p=0.91). In the adjusted analysis, the -786T>C polymorphism did not reach statistical significance.

CONCLUSION

There was no significant association between CSFP and 2 of the most common polymorphisms of the eNOS gene in post-PPCI patients.

摘要

目的

本研究旨在探讨内皮型一氧化氮合酶（eNOS）基因的两个多态性位点（-786T>C和+894G>T）与直接经皮冠状动脉介入治疗（PPCI）患者无复流/慢血流现象之间的关联。

方法

共纳入103例PPCI术后患者。冠状动脉无复流现象定义为心肌梗死溶栓（TIMI）血流分级为0-1级，冠状动脉慢血流现象（CSFP）定义为TIMI血流分级≤2级。

结果

由于PPCI术后出现无复流现象的患者数量较少（n=4），因此主要对CSFP组（n=20）和正常血流组（n=83）进行比较。eNOS -786T>C多态性的-786C等位基因携带者中CSFP的发生率更高（优势比[OR]：3.90；95%置信区间[CI]：0.87-17.45；p=0.07）。然而，未检测到eNOS +894G>T的+894T等位基因与CSFP之间存在此类关联（OR：0.92；95% CI：0.21-3.98；p=0.91）。在调整分析中，-786T>C多态性未达到统计学显著性。