通过多米诺N-H钯催化/无金属氧化C-H键活化合成杂环吲哚并吡嗪

Synthesis of Heteroannulated Indolopyrazines through Domino N-H Palladium-Catalyzed/Metal-Free Oxidative C-H Bond Activation.

作者信息

Kvashnin Yuriy A, Verbitskiy Egor V, Zhilina Ekaterina F, Rusinov Gennady L, Chupakhin Oleg N, Charushin Valery N

机构信息

I. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, S. Kovalevskaya Str., 22, Ekaterinburg 620108, Russia.

Ural Federal University, Mira St. 19, Ekaterinburg 620002, Russia.

出版信息

ACS Omega. 2020 Jun 18;5(25):15681-15690. doi: 10.1021/acsomega.0c01945. eCollection 2020 Jun 30.

A convenient approach to [1,2,5]oxadiazolo[3',4':5,6]pyrazino[2,3-]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald-Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured.