Järvholm B, Thorén K, Brolin I, Ericsson J, Morgan U, Tylen U, Bake B
Department of Occupational Medicine, Sahlgrenska Sjukhuset, Göteborg, Sweden.
Am J Ind Med. 1988;14(4):457-64. doi: 10.1002/ajim.4700140409.
In a cross-sectional study, 13 nonsmoking men with heavy exposure to paper dust were compared with 14 unexposed men, mainly office workers, employed at the same paper mill. They were studied using questionnaires, physical examinations, pulmonary function studies, and chest radiographs. Among those exposed there was an increased lung elastic recoil pressure (Pel) compared with controls which was significant (p less than 0.05) at the maximal level of total lung capacity (100% TLC). Furthermore, among the exposed workers there was also a significantly (p less than 0.05) decreased residual volume (RV). Two of the exposed men underwent lung biopsies, one of which showed fibrotic alveolar walls. Among the exposed there was also a significant (p less than 0.05) predominance of symptoms from the lower respiratory tract. We suggest that the observed pulmonary function impairment taken together with the histological examination of the lung biopsies are signs of a nonspecific reaction to high levels of paper dust.
在一项横断面研究中,将13名大量接触纸尘的不吸烟男性与14名在同一家造纸厂工作的未接触者(主要是办公室职员)进行了比较。通过问卷调查、体格检查、肺功能研究和胸部X光片对他们进行了研究。与对照组相比,接触者的肺弹性回缩压(Pel)有所增加,在肺总量最大水平(100% TLC)时具有显著性差异(p<0.05)。此外,接触工人的残气量(RV)也显著降低(p<0.05)。两名接触者接受了肺活检,其中一人显示肺泡壁纤维化。接触者中来自下呼吸道的症状也显著占优(p<0.05)。我们认为,观察到的肺功能损害以及肺活检的组织学检查结果表明是对高水平纸尘的非特异性反应。