（-）-2-甲氧基-2-丁烯酸内酯-3-肉桂酸酯的全合成及其抗菌潜力。
Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials.
作者信息
Said Madhukar S, Udavant Rohini, Sahu Amit Kumar, Khan AbuJunaid, Nayak Rashmi, Dastager Syed G, Kumar Pradeep, Gajbhiye Jayant
机构信息
Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
出版信息
Nat Prod Res. 2021 Dec;35(23):5177-5182. doi: 10.1080/14786419.2020.1789979. Epub 2020 Jul 9.
The first total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate (butenolide cinnamate) was achieved using commercially available starting material. The synthesized compound was found to have promising antibacterial activity against Gram-negative strains (ATCC 8739), (ATCC 23564) and (ATCC 19154) with a minimum inhibitory concentration of 2.0 µg/mL, 1.0 µg/mL and 2.0 µg/mL, respectively. Notably, the compound was more potent against Gram-negative test strains than the Gram-positive test strains.[Figure: see text].
使用市售起始原料首次完成了（-）-2-甲氧基-2-丁烯酸内酯-3-肉桂酸酯（丁烯酸内酯肉桂酸酯）的全合成。发现合成的化合物对革兰氏阴性菌株（ATCC 8739）、（ATCC 23564）和（ATCC 19154）具有良好的抗菌活性，其最低抑菌浓度分别为2.0μg/mL、1.0μg/mL和2.0μg/mL。值得注意的是，该化合物对革兰氏阴性测试菌株的活性比对革兰氏阳性测试菌株更强。[图：见正文]
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