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病灶内注射曲安奈德治疗眶周结节性筋膜炎:1例报告及文献复习

The management of periorbital nodular fasciitis using intra-lesional triamcinolone: a case report and review of the literature.

作者信息

Keren Shay, Hildebrand Darius, Wilson Shaun, McCallum Ewan, Norris Jonathan H

机构信息

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

Department of Paediatric Oncology, Children's Hospital, John Radcliffe Hospital, Oxford, UK.

出版信息

Orbit. 2021 Aug;40(4):333-337. doi: 10.1080/01676830.2020.1787465. Epub 2020 Jul 9.

Abstract

Nodular fasciitis (NF) is a subcutaneous, nodular, pseudo-sarcomatous, fibroblastic proliferation. It is rarely reported in the periorbital region and the management approach is variable.Presented is an eight-year-old female with a three month history of a periorbital mass. Incisional biopsy histologically confirmed nodular fasciitis with a unique gene translocation. The lesion was treated primarily with one intra-lesional injection of triamcinolone acetonide. Four months post-injection, the lesion resolved completely. No recurrence was seen at 12-months follow-up post-injection. No side effects were noted.To our knowledge. this is the first reported use of intra-lesional triamcinolone acetonide as a first-line treatment in periorbital NF. We found this to be a safe and effective treatment, which can obviate the need for surgical excision in a cosmetically sensitive region.

摘要

结节性筋膜炎(NF)是一种皮下结节状、假肉瘤样的成纤维细胞增生性病变。眼眶周围区域很少有相关报道,其治疗方法也各不相同。本文报告了一名8岁女性,眼眶周围肿物3个月。切开活检组织学确诊为结节性筋膜炎,伴有独特的基因易位。该病变主要通过病灶内注射一次曲安奈德进行治疗。注射后4个月,病变完全消退。注射后12个月随访未见复发。未观察到副作用。据我们所知,这是首次报道将病灶内注射曲安奈德作为眼眶周围NF的一线治疗方法。我们发现这是一种安全有效的治疗方法,可以避免在对美观敏感的区域进行手术切除。

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