Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Center of Expertise for Parkinson and Movement Disorders, Nijmegen, The Netherlands.
Department of Rehabilitation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Center of Expertise for Parkinson and Movement Disorders Nijmegen, The Netherlands.
J Parkinsons Dis. 2020;10(s1):S29-S36. doi: 10.3233/JPD-202135.
In people with young onset Parkinson's disease (YOPD), onset of symptoms is between 21 and 40 years of age. The distinction between YOPD and late-onset Parkinson's disease is supported by genetic differences (a genetic etiology is more common in people with YOPD) and clinical differences (e.g., dystonia and levodopa-induced dyskinesias are more common inYOPD). Moreover, people with YOPD tend to have different family and societal engagements compared to those with late-onset PD. These unique features have implications for clinical management, and call for a tailored multidisplinary approach involving shared-decision making.
在早发性帕金森病（YOPD）患者中，症状发作的年龄在 21 至 40 岁之间。YOPD 和晚发性帕金森病的区别在于遗传差异（YOPD 患者中遗传病因更为常见）和临床差异（例如，YOPD 患者更常见的是肌张力障碍和左旋多巴诱导的运动障碍）。此外，与晚发性 PD 患者相比，YOPD 患者的家庭和社会参与度往往不同。这些独特的特征对临床管理具有重要意义，并需要采用涉及共同决策的定制多学科方法。
