Center for Surgery and Public Health, Harvard Medical School, Harvard T. H. Chan School of Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, MA.
Center for Surgery and Public Health, Harvard Medical School, Harvard T. H. Chan School of Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, MA.
Surgery. 2020 Oct;168(4):684-689. doi: 10.1016/j.surg.2020.05.015. Epub 2020 Jul 9.
Rib fractures are painful injuries that are treated with aggressive analgesia, which can include opioids. We sought to evaluate the patterns and predictors of opioid prescription and sustained use for rib fracture patients to identify opportunities for opiate reduction.
We used TRICARE claims data (2006-2014) to identify adult (18-64 years) patients presenting to the emergency department with rib fracture(s) and isolated chest trauma. We used logistic regression and Cox proportional hazards model to identify factors associated with opioid prescription and duration of use.
We identified 29,943 patients meeting inclusion criteria, and 2,542 (9%) patients were prescribed opioids. When prescribed, the median duration opioid use was 16 days (interquartile range 6-31) for opioid naïve patients, compared with 36 days (interquartile range 15-134) for those with prior opioid exposure. Increased number of ribs fractured (6+ fractures) (odds ratio 2.96 [95% confidence interval 2.23-3.94], P < .001) and prior opioid exposure (odds ratio 32.95 [29.36-36.99], P < .001) were significant predictors of initial opioid prescription. Patients with prior opioid exposure (hazard ratio 0.47 [0.43-0.52], P < .001) had lower likelihood of opioid discontinuation. Injury characteristics did not significantly predict discontinuation.
Prior opioid exposure was the strongest predictor of sustained opioid use after rib fractures, while the severity of injury did not predict the duration of use.
肋骨骨折是一种疼痛的损伤,需要积极的镇痛治疗,包括使用阿片类药物。我们旨在评估肋骨骨折患者阿片类药物处方和持续使用的模式和预测因素,以确定减少阿片类药物使用的机会。
我们使用 TRICARE 理赔数据(2006-2014 年),确定了因肋骨骨折和孤立性胸部外伤到急诊就诊的成年(18-64 岁)患者。我们使用逻辑回归和 Cox 比例风险模型,确定与阿片类药物处方和使用时间相关的因素。
我们确定了符合纳入标准的 29943 名患者,其中 2542 名(9%)患者开具了阿片类药物。对于阿片类药物初治患者,中位数阿片类药物使用时间为 16 天(四分位距 6-31 天),而有阿片类药物使用史的患者为 36 天(四分位距 15-134 天)。骨折肋骨数量增加(6 根以上骨折)(比值比 2.96[95%置信区间 2.23-3.94],P<.001)和有阿片类药物使用史(比值比 32.95[29.36-36.99],P<.001)是初始阿片类药物处方的显著预测因素。有阿片类药物使用史的患者(风险比 0.47[0.43-0.52],P<.001)停止使用阿片类药物的可能性较低。损伤特征不能显著预测停药。
阿片类药物使用史是肋骨骨折后持续使用阿片类药物的最强预测因素,而损伤严重程度不能预测使用时间。