Foschi Claudio, Zagarrigo Manuel, Belletti Matteo, Marangoni Antonella, Re Maria Carla, Gaspari Valeria
Microbiology, DIMES, University of Bologna, via Massarenti 9, Bologna, Italy.
Dermatology, DIMES, University of Bologna, via Massarenti 9, Bologna, Italy.
New Microbiol. 2020 Jul;43(3):115-120. Epub 2020 Jun 13.
Chlamydia trachomatis and Neisseria gonorrhoeae are the most common agents of bacterial sexually transmitted infections (STIs) worldwide. Here, we evaluated genital and extra-genital C. trachomatis and N. gonorrhoeae infection prevalence in a cohort of young women attending an STI Outpatients Clinic in Italy. From May 2019 to December 2019, 134 women aged 18-26 years were enrolled. A vaginal, a pharyngeal and a rectal swab for the molecular detection of C. trachomatis and N. gonorrhoeae were collected from each patient. Chlamydia-positive samples underwent a molecular genotyping based on pmpH gene. Total prevalence of C. trachomatis and N. gonorrhoeae infections was 17.9% and 11.2%, respectively. Chlamydial infections were prevalent in the urogenital (16.4%) and rectal (13.4%) sites, whereas N. gonorrhoeae predominated in the genital (7.4%) and pharyngeal (6%) mucosa. Overall, 5.2% of cases would have been missed if extra-genital sites had not been tested. Notably, 60% of women with a rectal infection did not report anal sex. A history of sexual contacts with a positive partner (P=0.03) and a history of ≥3 partners in the last 6 months (P=0.0075) were highly predictive of a bacterial STI. No cases of lymphogranuloma venereum were found. These data could help set up effective strategies to prevent the spread of STIs.
沙眼衣原体和淋病奈瑟菌是全球细菌性性传播感染（STIs）最常见的病原体。在此，我们评估了意大利一家性传播感染门诊就诊的年轻女性队列中生殖系统和生殖系统外的沙眼衣原体和淋病奈瑟菌感染率。2019年5月至2019年12月，招募了134名年龄在18 - 26岁的女性。从每位患者采集阴道、咽部和直肠拭子，用于沙眼衣原体和淋病奈瑟菌的分子检测。沙眼衣原体阳性样本基于pmpH基因进行分子基因分型。沙眼衣原体和淋病奈瑟菌感染的总患病率分别为17.9%和11.2%。衣原体感染在泌尿生殖系统（16.4%）和直肠（13.4%）部位较为普遍，而淋病奈瑟菌在生殖器（7.4%）和咽部（6%）黏膜中占主导。总体而言，如果未对生殖系统外部位进行检测，5.2%的病例将会漏诊。值得注意的是，60%直肠感染女性未报告有肛交史。与阳性伴侣有性接触史（P = 0.03）以及在过去6个月内有≥3个性伴侣史（P = 0.0075）是细菌性性传播感染的高度预测因素。未发现性病性淋巴肉芽肿病例。这些数据有助于制定有效的策略来预防性传播感染的传播。
