通过 SABRE-SHEATH 极化的甲硝唑中的 N 弛豫动力学定量四极子阱的影响。
Quantifying the effects of quadrupolar sinks viaN relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH.
机构信息
Department of Chemistry, Integrative Biosciences (Ibio), Wayne State University, Karmanos Cancer Institute (KCI), Detroit, Michigan 48202, USA.
出版信息
Chem Commun (Camb). 2020 Aug 18;56(64):9098-9101. doi: 10.1039/d0cc03994b. Epub 2020 Jul 14.
Abstract
N spin-lattice relaxation dynamics in metronidazole-N and metronidazole-N isotopologues are studied for rational design of N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar N nucleus within the spin-relayed N-N network.
摘要
研究了甲硝唑-N 和甲硝唑-N 同位素的 N 核自旋晶格弛豫动力学，以合理设计富含 N 的生物分子，通过微特斯拉场中的可逆交换进行信号放大。N 弛豫动力学图谱揭示了与极化转移催化剂和自旋传递网络内的四极 N 核相互作用的有害影响。
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