Department of Theranostics and Nuclear Medicine, St Vincent's Hospital, Sydney, Australia; University of New South Wales, Sydney, Australia.
Semin Oncol Nurs. 2020 Aug;36(4):151052. doi: 10.1016/j.soncn.2020.151052. Epub 2020 Jul 13.
Prostate-specific membrane antigen (PSMA) theranostics is changing the face of prostate cancer diagnosis and therapy. PSMA, a transmembrane protein over-expressed in many prostate cancers, is a promising target for theranostics. Theranostics is the concept of small molecule proteins that are labelled to different radionuclides and can be used for either diagnosis or therapy, dependent on whether they are labelled with an imaging or therapy radionuclide. By directly targeting the cancer cells with imaging and then for therapy, this approach embodies the philosophy of precision medicine - right drug, right time, right dose. The question is how to best utilise these new imaging and therapy agents in clinical practice. This review will evaluate the importance of PSMA in prostate cancer, its role in diagnostic imaging, and its potential as a therapy of advanced prostate cancer.
Electronic databases including MEDLINE, Scopus, professional websites were searched.
PSMA-directed theranostics has an expanding role in prostate cancer because of its utility as a sensitive diagnostic tool that can be coupled with efficacious and low-toxicity therapeutic options. Ongoing research is required to determine how to use this effective tool for best patient care.
PSMA theranostics is rapidly being incorporated into the routine care of men with prostate cancer. Understanding its strengths, its limitations, and where it may be valuable in clinical care is important in undertaking best patient practice.
前列腺特异性膜抗原（PSMA）治疗学正在改变前列腺癌诊断和治疗的格局。PSMA 是一种在许多前列腺癌中过度表达的跨膜蛋白，是治疗学的一个有前途的靶点。治疗学是指对小分子蛋白进行标记，使其与不同的放射性核素结合，可以用于诊断或治疗，具体取决于它们是否与成像或治疗放射性核素标记。通过直接用成像靶向癌细胞，然后进行治疗，这种方法体现了精准医学的理念——正确的药物、正确的时间、正确的剂量。问题是如何在临床实践中最好地利用这些新的成像和治疗剂。这篇综述将评估 PSMA 在前列腺癌中的重要性、它在诊断成像中的作用以及它作为晚期前列腺癌治疗的潜力。
电子数据库包括 MEDLINE、Scopus 和专业网站进行了搜索。
由于 PSMA 作为一种敏感的诊断工具具有实用性，并且可以与有效且低毒性的治疗选择相结合，因此 PSMA 靶向治疗学在前列腺癌中的作用不断扩大。需要进行进一步的研究来确定如何使用这种有效的工具为患者提供最佳护理。
PSMA 治疗学正在迅速纳入前列腺癌患者的常规治疗中。了解其优势、局限性以及在临床护理中的价值对于实施最佳患者护理非常重要。
