[rs1495741单核苷酸多态性与抗结核药物性肝损伤易感性的关联]

[Association of rs1495741 Single Nucleotide Polymorphism with Susceptibility of Anti-tuberculosis Drug-induced Hepatotoxicity].

作者信息

Wang Ming-Gui, Zhang Yao-Zhi, Zhang Meng, He Jian-Qing

机构信息

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):910-913.

PMID:32677403

Abstract

OBJECTIVE

To investigate the potential association between the polymorphism of N- acetyltransferase 2 () gene and anti-tuberculosis drug-induced hepatotoxicity (ATDH) in Han population.

METHODS

The SNP rs1495741 was genotyped by using multiplex ligation detection reaction (MLDR) technique, and logistic regression analysis was used to analyze the association between this SNP and the susceptibility of ATDH.

RESULTS

There were 247 PTB patients enrolled in this study, including 24 ATDH, and 223 controls (PTB without ATDH). No significant difference in genotype and allele distribution was observed for rs1495741 in between the controls and ATDH group. After adjusting age, sex, body mass index (BMI) and smoking history, the SNP of rs1495741 showed a significant association with ATDH 〔odds ratio ()=2.728 (95% confidence interval: 1.022-7.281)〕 under recessive model (AA vs. GA+GG).

CONCLUSIONS

The rs1495741 in NAT2 seems related to the development of ATDH among PTB patients, AA genotype of rs1495741 may be a causative factor for increased susceptibility to ATDH.

摘要

目的

探讨汉族人群中N - 乙酰转移酶2（NAT2）基因多态性与抗结核药物性肝毒性（ATDH）之间的潜在关联。

方法

采用多重连接检测反应（MLDR）技术对单核苷酸多态性（SNP）rs1495741进行基因分型，并运用逻辑回归分析该SNP与ATDH易感性之间的关联。

结果

本研究共纳入247例肺结核（PTB）患者，其中24例发生ATDH，223例为对照（未发生ATDH的PTB患者）。rs1495741在对照组和ATDH组之间的基因型和等位基因分布未观察到显著差异。在调整年龄、性别、体重指数（BMI）和吸烟史后，rs1495741的SNP在隐性模型（AA与GA + GG相比）下与ATDH呈显著关联〔优势比（OR）=2.728（95%置信区间：1.022 - 7.281）〕。