Department of Dermatology, Research Division of Biology and Pathobiology of the Skin, Medical University of Vienna, Vienna, A-1090, Austria.
Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Curr Med Sci. 2020 Jun;40(3):570-573. doi: 10.1007/s11596-020-2192-2. Epub 2020 Jul 17.
Cerebellar degeneration-related antigen 1 (CDR1) was described to be expressed in the nervous system and in different types of cancer tissues. In the present study, we demonstrate that CDR1 is in addition ubiquitously expressed in human epidermis, dermis and isolated skin cells. Both CDR1 mRNA and protein were detected in human skin-derived mast cells, melanocytes, fibroblasts and keratinocytes, suggesting that CDR1 does not have a neuron-specific function.
小脑退行性变相关抗原 1（CDR1）被描述为在神经系统和不同类型的癌组织中表达。在本研究中，我们证明 CDR1 还广泛表达于人类表皮、真皮和分离的皮肤细胞中。人皮肤来源的肥大细胞、黑素细胞、成纤维细胞和角质形成细胞中均检测到 CDR1mRNA 和蛋白，提示 CDR1 不具有神经元特异性功能。
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