较低的血清嗜铬粒蛋白B水平与1型糖尿病以及接受强化保守胰岛素治疗的2型糖尿病患者相关。
Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment.
作者信息
Herold Zoltan, Herold Magdolna, Rosta Klara, Doleschall Marton, Somogyi Aniko
机构信息
Department of Internal Medicine and Hematology, Semmelweis University, H-1088 Szentkiralyi u. 46, Budapest, Hungary.
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
出版信息
Diabetol Metab Syndr. 2020 Jul 14;12:61. doi: 10.1186/s13098-020-00569-5. eCollection 2020.
BACKGROUND
Chromogranin B (CgB) plays an important role in the physiological insulin secretion of pancreatic beta cells. Serum CgB levels were investigated in type 1 and type 2 diabetes patients in a cross-sectional study.
METHODS
An observational cross-sectional study was performed with the inclusion of 94 control subjects, 100 type 1 and 100 type 2 diabetes patients, at the Metabolic Outpatient Clinic of the Department of Internal Medicine and Hematology, Semmelweis University. Serum CgB levels were measured with enzyme-linked immunosorbent assay.
RESULTS
Serum CgB level was lower in type 1 diabetes patients than in matched control subjects ( = 0.0241), while they were equal in type 2 diabetes patients and controls ( = 0.1698). The subgroup of type 2 diabetes patients who received intensive conservative insulin treatment had significantly lower CgB levels compared to those with other regimens of antidiabetic therapies ( = 0.0283).
CONCLUSION
The lower serum CgB levels in the patients with type 1 diabetes and the type 2 diabetes patients with progressed disease stage suggested that the CgB production might be decreased due to the beta cell destruction and depletion.
背景
嗜铬粒蛋白B（CgB）在胰腺β细胞的生理性胰岛素分泌中起重要作用。在一项横断面研究中，对1型和2型糖尿病患者的血清CgB水平进行了调查。
方法
在塞梅尔维斯大学内科和血液学系代谢门诊进行了一项观察性横断面研究，纳入了94名对照受试者、100名1型糖尿病患者和100名2型糖尿病患者。采用酶联免疫吸附测定法测量血清CgB水平。
结果
1型糖尿病患者的血清CgB水平低于匹配的对照受试者（P = 0.0241），而2型糖尿病患者和对照受试者的血清CgB水平相等（P = 0.1698）。与接受其他抗糖尿病治疗方案的患者相比，接受强化保守胰岛素治疗的2型糖尿病患者亚组的CgB水平显著降低（P = 0.0283）。
结论
1型糖尿病患者和疾病进展期的2型糖尿病患者血清CgB水平较低，提示由于β细胞破坏和耗竭，CgB产生可能减少。
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