衰老中的氧化还原失衡与代谢改变：对癌症和心脏疾病的影响。意大利心脏病学会（SIC）心脏毒性与心脏保护工作组的综述

Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC).

作者信息

Mercurio Valentina, Cuomo Alessandra, Cadeddu Dessalvi Christian, Deidda Martino, Di Lisi Daniela, Novo Giuseppina, Manganaro Roberta, Zito Concetta, Santoro Ciro, Ameri Pietro, Spallarossa Paolo, Arboscello Eleonora, Tocchetti Carlo Gabriele, Penna Claudia

机构信息

Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy.

Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy.

出版信息

Antioxidants (Basel). 2020 Jul 21;9(7):641. doi: 10.3390/antiox9070641.

DOI:10.3390/antiox9070641

PMID:32708201

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7402085/

Abstract

Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS are also cancer risk factors, such as the consumption of high calorie-food or high fat intake, low fibre intake, and sedentary lifestyle. Other common aspects of both cancer and MetS are oxidative stress and inflammation. In addition, some anticancer treatments can induce cardiotoxicity, including, for instance, left ventricular (LV) dysfunction and heart failure (HF), endothelial dysfunction and hypertension. In this review, we analyse several aspects of MetS, cancer and cardiotoxicity from anticancer drugs. In particular, we focus on oxidative stress in ageing, cancer and CV diseases, and we analyse the connections among CV risk factors, cancer and cardiotoxicity from anticancer drugs.

摘要

代谢综合征（MetS）是心血管（CV）疾病公认的危险因素。此外，多项研究表明，MetS与成年人患癌风险增加相关。MetS与癌症之间的联系机制尚未完全明确。MetS涉及的一些危险因素也是癌症风险因素，如高热量食物的摄入或高脂肪饮食、低纤维摄入以及久坐不动的生活方式。癌症和MetS的其他常见方面是氧化应激和炎症。此外，一些抗癌治疗可诱发心脏毒性，包括例如左心室（LV）功能障碍和心力衰竭（HF）、内皮功能障碍和高血压。在本综述中，我们分析了MetS、癌症以及抗癌药物所致心脏毒性的几个方面。特别是，我们关注衰老、癌症和心血管疾病中的氧化应激，并分析心血管危险因素、癌症和抗癌药物所致心脏毒性之间的联系。