Department of Pediatrics, The American Family Children's Hospital, University of Wisconsin Hospital and Clinics, 1675 Highland Ave, Madison, WI, 53792, USA.
School of Medicine and Public Health, The American Family Children's Hospital, University of Wisconsin Hospital and Clinics, 1675 Highland Ave, Madison, WI, 53792, USA.
Pediatr Cardiol. 2020 Dec;41(8):1704-1713. doi: 10.1007/s00246-020-02431-x. Epub 2020 Jul 30.
Infants undergoing congenital heart surgery (CHS) with cardiopulmonary bypass (CPB) are at risk of acute kidney injury (AKI) and fluid overload. We hypothesized that placement of a passive peritoneal drain (PPD) can improve postoperative fluid output in such infants. We analyzed 115 consecutive patients, age birth to 60 days, admitted to the PICU after CHS with CPB between 2012 and 2018. Patients who needed postoperative ECMO were excluded. Linear and logistic regression models compared postoperative fluid balances, diuretics administration, AKI, vasoactive-inotropic scores (VIS), time intubated, and length of stay after adjusting for pre/operative predictors including STAT category, bypass time, age, weight, and open chest status. PPD patients had higher STAT category (p = 0.001), longer CPB times (p = 0.001), and higher VIS on POD 1-3 (p ≤ 0.005 daily). PPD patients also had higher AKI rates (p = 0.01) that did not reach significance in multivariable modeling. There were no postoperative deaths. Postoperative hours of intubation, hospital length of stay, and POD 1-5 fluid intake did not differ between groups. Over POD 1-5, PPD use accounted for 48.8 mL/kg increased fluid output (95% CI [2.2, 95.4], p = 0.043) and 3.41 mg/kg less furosemide administered (95% CI [1.69, 5.14], p < 0.001). No PPD complications were observed. Although PPD placement did not affect end-outcomes, it was used in higher acuity patients. PPD placement is associated with improved fluid output despite lower diuretic administration and may be a useful postoperative fluid management adjunct in some complex CHS patients.
在接受体外循环(CPB)先天性心脏手术(CHS)的婴儿中,存在急性肾损伤(AKI)和液体超负荷的风险。我们假设放置被动腹膜引流(PPD)可以改善此类婴儿的术后液体输出。我们分析了 2012 年至 2018 年期间在 CPB 后接受 CHS 的 115 例连续患者,年龄从出生到 60 天。排除需要术后 ECMO 的患者。线性和逻辑回归模型比较了术后液体平衡、利尿剂使用、AKI、血管活性-正性肌力评分(VIS)、插管时间和住院时间,调整了 STAT 类别、旁路时间、年龄、体重和开胸状态等术前/术后预测因素。PPD 患者的 STAT 类别更高(p=0.001),CPB 时间更长(p=0.001),术后 1-3 天 VIS 更高(p≤0.005 每日)。PPD 患者的 AKI 发生率更高(p=0.01),但多变量建模未达到显著性。术后无死亡。两组患者术后插管时间、住院时间和术后 1-5 天液体摄入量无差异。在 POD 1-5 期间,PPD 使用量使液体输出增加了 48.8mL/kg(95%CI [2.2, 95.4],p=0.043),并减少了 3.41mg/kg 的呋塞米使用量(95%CI [1.69, 5.14],p<0.001)。未观察到 PPD 并发症。尽管 PPD 放置并未影响最终结果,但它用于更高危的患者。尽管利尿剂用量减少,但 PPD 放置与改善的液体输出相关,并且可能是某些复杂 CHS 患者术后液体管理的有用辅助手段。