可乐定与氯氮䓬治疗急性酒精戒断的比较：初步报告。

Clonidine versus chlordiazepoxide in acute alcohol withdrawal: a preliminary report.

作者信息

Baumgartner G R

机构信息

William S. Hall Psychiatric Institute, University of South Carolina School of Medicine, Department of Neuropsychiatry and Behavioral Science, Columbia 29202.

出版信息

South Med J. 1988 Jan;81(1):56-60. doi: 10.1097/00007611-198801000-00012.

DOI:10.1097/00007611-198801000-00012

PMID:3276009

Abstract

The findings presented here are from the first reported comparison and double-blind evaluation of 20 patients randomly assigned to either chlordiazepoxide (n = 10) or clonidine (n = 10) for the treatment of acute alcohol withdrawal syndrome. Analysis of the study data demonstrated more favorable scores on tests of alcohol withdrawal symptoms (AWS), and better control of blood pressure, pulse, and respiratory rate with clonidine than with chlordiazepoxide therapy. In all other comparisons, clonidine was at least as efficacious. Clonidine may 'represent a new and possibly even superior pharmacologic treatment in the management of acute alcohol withdrawal syndrome.

摘要

本文呈现的研究结果来自首次报道的对20例急性酒精戒断综合征患者的比较及双盲评估，这些患者被随机分为两组，一组接受氯氮䓬治疗（n = 10），另一组接受可乐定治疗（n = 10）。研究数据分析表明，与氯氮䓬治疗相比，可乐定在酒精戒断症状（AWS）测试中得分更优，对血压、脉搏和呼吸频率的控制更好。在所有其他比较中，可乐定至少具有同等疗效。可乐定可能代表了一种治疗急性酒精戒断综合征的新的、甚至可能更优的药物治疗方法。