Wang H B, Zhao L M, Hong K, Mao J M, Liu D F, Lin H C, Jiang H
Peking University Third Hospital Reproductive Center, Beijing 100191, China.
Department of Urology, Ningcheng County Central Hospital, Chifeng 024200, Inner Mongolia, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Aug 18;52(4):642-645. doi: 10.19723/j.issn.1671-167X.2020.04.008.
To evaluate the utility of transurethral seminal vesiculoscopy with a slender ureteroscope in the treatment of severe oligoasthenozoospermia secondary incomplete ejaculatory duct obstruction (EDO).
From March 2018 to September 2018, the clinical data of 8 patients with severe oligoasthenozoospermia secondary incomplete EDO treated by the technique of transurethral seminal vesiculoscopy in the Peking University Third Hospital Reproductive Center were analyzed. Preoperative routine included semen analysis, hormone determination, transrectal ultrasonography, pelvic magne-tic resonance examination and other examinations. All the patients were diagnosed with severe oligoasthenozoospermia secondary to incomplete EDO. All the patients were operated by the same surgeon with multiple cases of experience in transurethral surgery, and 1 year follow-up was conducted to evaluate the surgical effect.
The average age of the 8 patients was 29 years, and the average operation time was 32 min. Preoperative transrectal ultrasound indicated 6 cases of ejaculatory duct cyst or Mullerian cyst, 1 case of prostate calcification and bilateral seminal vesicle dilatation. The average maximum transverse diameter of the right seminal vesicle in pelvic MRI was 33.60 mm (24.63-42.28 mm), the average maximum transverse diameter of the left seminal vesicle was 32.85 mm (25.91-44.89 mm), the ave-rage maximum antero-posterior diameter was 27.99 mm (21.36-33.12 mm), the average maximum width of the seminal vesicle duct was 10.53 mm (5.93-19.39 mm). There were 5 cases of ejaculatory duct cyst, 2 cases of seminal vesicle hemorrhage, and 1 case of Mullerian cyst. The semen volume [(2.64±0.80) mL], the sperm concentration [(49.76±8.50)×10/mL], and the motility (grade a+b) [(25.76±6.48)%] in postoperation were significantly higher than those in preoperation [(1.46±0.50) mL, (28.78±5.17)×10/mL, and (2.88±0.93)%, < 0.05]. Two patients conceived naturally during the follow-up of 6 months after surgery. There were no severe complications, such as retrograde ejaculation, urinary incontinence or rectal injury.
The technique of transurethral seminal vesiculoscopy is safe and effective for treating severe oligoasthenozoospermia secondary to incomplete EDO. However, due to the small sample size of this study, short follow-up time, and the uncertainty in seminal vesicle surgery, it still needs to be further confirmed by long-term follow-up studies with large samples.
评估经尿道细输尿管镜下精囊镜检查在治疗继发于不完全射精管梗阻(EDO)的严重少弱精子症中的应用价值。
分析2018年3月至2018年9月北京大学第三医院生殖中心采用经尿道精囊镜技术治疗的8例继发于不完全EDO的严重少弱精子症患者的临床资料。术前常规检查包括精液分析、激素测定、经直肠超声检查、盆腔磁共振检查等。所有患者均诊断为继发于不完全EDO的严重少弱精子症。所有患者均由同一位具有多例经尿道手术经验的外科医生进行手术,并进行1年随访以评估手术效果。
8例患者平均年龄29岁,平均手术时间32分钟。术前经直肠超声显示6例射精管囊肿或苗勒管囊肿,1例前列腺钙化并双侧精囊扩张。盆腔磁共振成像显示右侧精囊平均最大横径为33.60mm(24.63 - 42.28mm),左侧精囊平均最大横径为32.85mm(25.91 - 44.89mm),平均最大前后径为27.99mm(21.36 - 33.12mm),精囊管平均最大宽度为10.53mm(5.93 - 19.39mm)。术中发现射精管囊肿5例,精囊出血2例,苗勒管囊肿1例。术后精液量[(2.64±0.80)mL]、精子浓度[(49.76±8.50)×10⁶/mL]及活动率(a + b级)[(25.76±6.48)%]均显著高于术前[(1.46±0.50)mL、(28.78±5.17)×10⁶/mL及(2.88±0.93)%,P < 0.05]。术后随访6个月内有2例患者自然受孕。未出现逆行射精、尿失禁或直肠损伤等严重并发症。
经尿道精囊镜技术治疗继发于不完全EDO的严重少弱精子症安全有效。然而,由于本研究样本量小、随访时间短以及精囊手术存在不确定性,仍需大样本长期随访研究进一步证实。