Chin Sang Ouk, Ha In Gyoon, Rhee Sang Youl, Jeong Su Jin, Chon Suk, Kim Sung Hoon, Ahn Kyu Jeung, Baik Sei Hyun, Park Yongsoo, Nam Moon Suk, Lee Kwan Woo, Woo Jeong Taek
Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Statistics Support Department, Kyung Hee University, Medical Center Science Research Institute, Seoul, Republic of Korea.
Int J Endocrinol. 2020 Jul 24;2020:9879517. doi: 10.1155/2020/9879517. eCollection 2020.
This cross-sectional study based on the Korean National Diabetes Program 2 registry used its baseline clinical data collected from seven participating university hospitals in Korea. Patients with no significant changes in their oral hypoglycemic agents and no diabetes-related complications within the year prior to participation were enrolled. Patients' clinical characteristics according to metformin use were analyzed.
Among 858 subjects included in the analyses, 706 were metformin users and 152 were nonmetformin users. Metformin users were significantly younger and had higher and glycated hemoglobin with significantly lower rates of accompanying microvascular complications such as retinopathy, cataracts, overt proteinuria, renal insufficiency, and peripheral neuropathy than nonusers. Meanwhile, there was a significantly lower prevalence of malignancy and depression among metformin users. These associations remained significant in multivariate analyses. The prevalence rate of macrovascular complications was not significantly different between the two groups.
There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin use among Korean type 2 diabetes patients. Long-term follow-up of these patients is necessary to observe how this difference will affect clinical outcomes for these patients.
本横断面研究基于韩国国家糖尿病项目2登记处的数据，使用了从韩国七家参与研究的大学医院收集的基线临床数据。纳入参与前一年内口服降糖药无显著变化且无糖尿病相关并发症的患者。分析了根据二甲双胍使用情况的患者临床特征。
在纳入分析的858名受试者中，706名使用二甲双胍，152名未使用二甲双胍。与未使用者相比，二甲双胍使用者明显更年轻，糖化血红蛋白水平更高，伴有视网膜病变、白内障、显性蛋白尿、肾功能不全和周围神经病变等微血管并发症的发生率显著更低。同时，二甲双胍使用者中恶性肿瘤和抑郁症的患病率显著更低。这些关联在多变量分析中仍然显著。两组间大血管并发症的患病率无显著差异。
韩国2型糖尿病患者中，根据二甲双胍使用情况，临床特征和合并症患病率存在显著差异。有必要对这些患者进行长期随访，以观察这种差异将如何影响这些患者的临床结局。
