Village Podiatry Centers, Smyrna, GA, US.
J Wound Care. 2020 Aug 1;29(Sup8):S12-S17. doi: 10.12968/jowc.2020.29.Sup8.S12.
The objective of this study was to assess the clinical effectiveness of surgically implanted cryopreserved human umbilical cord allograft in treating hard-to-heal wounds with and without osteomyelitis.
In this single-centre, retrospective investigation, wounds (average size 6.9±10.1cm) were included for analysis that had failed prior standard wound care for an average of 14.4±8.0 weeks.
After surgical implantation of cryopreserved umbilical cord between the deep tissue planes, 20 (95%) of the 21 wounds included in the study achieved complete closure in a median time of 7.8 weeks (range: 1-68) despite presence of residual osteomyelitis in 15 cases. A total of 12 wounds (57.1%) healed by 12 weeks, and 16 (76.2%) wounds healed by 24 weeks. A patient who presented with a limb-threatening calcaneal ulcer that was complicated by osteomyelitis at the time of treatment required subsequent amputation. No adverse events or complications related to cryopreserved umbilical cord were observed.
The results suggest that surgical implantation of cryopreserved umbilical cord allograft may be a safe and effective treatment in improving healing of hard-to-heal wounds. Further prospective, randomised controlled trials are warranted.
本研究旨在评估手术植入冷冻保存的人脐带同种异体移植物治疗伴有和不伴有骨髓炎的难愈性伤口的临床效果。
在这项单中心回顾性研究中，纳入了分析的伤口（平均大小 6.9±10.1cm），这些伤口在经历了平均 14.4±8.0 周的标准伤口护理失败后仍未愈合。
在深层组织平面之间植入冷冻保存的脐带后，尽管 15 例存在残余骨髓炎，但 21 例纳入研究的伤口中有 20 例（95%）在中位数为 7.8 周（范围：1-68）的时间内完全闭合。12 例（57.1%）伤口在 12 周内愈合，16 例（76.2%）伤口在 24 周内愈合。一名患有跟骨溃疡且伴有骨髓炎的肢体威胁性患者在治疗时需要后续截肢。未观察到与冷冻保存脐带相关的不良事件或并发症。
结果表明，手术植入冷冻保存的脐带同种异体移植物可能是改善难愈性伤口愈合的一种安全有效的治疗方法。需要进一步进行前瞻性、随机对照试验。
Zotero 插件