Liver Unit, Albert Einstein Hospital, 05652-900 São Paulo, Brazil.
Albert Einstein Jewish Institute for Education and Research, 05652-900 São Paulo, Brazil.
Int J Mol Sci. 2020 Aug 12;21(16):5791. doi: 10.3390/ijms21165791.
Tumour recurrence is currently a hot topic in liver transplantation. The basic mechanisms are increasingly discussed, and, for example, recurrence of hepatocellular carcinoma is often described in pre-injured donor livers, which frequently suffer from significant ischemia/reperfusion injury. This review article highlights the underlying mechanisms and describes the specific tissue milieu required to promote tumour recurrence after liver transplantation. We summarise the current literature in this field and show risk factors that contribute to a pro-tumour-recurrent environment. Finally, the potential role of new machine perfusion technology is discussed, including the most recent data, which demonstrate a protective effect of hypothermic oxygenated perfusion before liver transplantation.
肿瘤复发目前是肝移植领域的一个热点话题。基本机制越来越受到讨论，例如，肝细胞癌的复发常发生于供肝预先受损的情况下，这些供肝常遭受严重的缺血/再灌注损伤。本文综述了相关的潜在机制，并描述了肝移植后促进肿瘤复发所需的特定组织微环境。我们总结了该领域的现有文献，并指出了导致肿瘤复发倾向环境的危险因素。最后，讨论了新的机器灌注技术的潜在作用，包括最近的数据，这些数据表明肝移植前低温氧合灌注具有保护作用。
