Hoilat Gilles J., Rentea Rebecca M.
University of Iowa Hospital & Clinics
Children's Mercy
Crohn disease is a chronic inflammatory bowel disease (IBD), first described by Crohn, Ginsberg, and Oppenheimer in 1932. It usually presents as a transmural granulomatous inflammation affecting the gastrointestinal tract, most commonly the ileum, colon, or both. The disease prevalence is on the rise with the highest incidence seen in North America, the United Kingdom, and northern Europe. Patients usually present with chronic diarrhea, often accompanied by abdominal pain, weight loss, and blood or mucus in the stools. Extraintestinal manifestations of IBD generally occur in 25 to 40%. Inflammatory manifestations can also occur outside of the gastrointestinal tract within the skin, eyes, liver, and joints. Crohn disease is diagnosed clinically based on clinical signs and symptoms, imaging, including endoscopic with biopsy and tissue information in addition to laboratory results. Intestinal complications of Crohn disease include obstruction and perforation of the small intestine or colon, abscesses, fistulas, intestinal bleeding, and strictures. Strictures are narrowed segments of intestine that usually result in bowel obstruction and can be debilitating in patients with Crohn disease. Strictureplasty is a surgical procedure that relieves bowel narrowing secondary to scar tissue formation that usually accumulates in the intestinal wall from repeated inflammation and healing in Crohn disease. It is a safe and effective procedure that will preserve the bowel length and prevent metabolic complications associated with short gut syndrome in patients with symptomatic obstruction.
克罗恩病是一种慢性炎症性肠病(IBD),1932年由克罗恩、金斯伯格和奥本海默首次描述。它通常表现为累及胃肠道的透壁性肉芽肿性炎症,最常见于回肠、结肠或两者。该病的患病率呈上升趋势,在北美、英国和北欧发病率最高。患者通常表现为慢性腹泻,常伴有腹痛、体重减轻以及粪便带血或黏液。IBD的肠外表现一般发生在25%至40%的患者中。炎症表现也可出现在胃肠道以外的皮肤、眼睛、肝脏和关节。克罗恩病根据临床体征和症状、影像学检查(包括内镜检查及活检和组织信息)以及实验室检查结果进行临床诊断。克罗恩病的肠道并发症包括小肠或结肠梗阻、穿孔、脓肿、瘘管、肠道出血和狭窄。狭窄是肠道变窄的部分,通常会导致肠梗阻,对克罗恩病患者可能造成虚弱。狭窄成形术是一种外科手术,可缓解因瘢痕组织形成导致的肠道狭窄,这种瘢痕组织通常因克罗恩病反复炎症和愈合而在肠壁堆积。这是一种安全有效的手术,可保留肠道长度,并预防有症状性梗阻患者出现与短肠综合征相关的代谢并发症。