顺铂及其类似物TNO-6在酵母中的细胞毒性和遗传毒性作用的比较研究。

A comparative study of the cytotoxic and genotoxic effects of cisplatin and its analogue, TNO-6, in yeast.

作者信息

Hannan M A

机构信息

Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

出版信息

Mutat Res. 1988 Mar;198(1):69-72. doi: 10.1016/0027-5107(88)90041-3.

DOI:10.1016/0027-5107(88)90041-3

PMID:3280985

Abstract

The antitumour drug cisplatin and its analogue, TNO-6, were studied for their cytotoxic, mutagenic and recombinagenic effects in a diploid strain (D7) of the yeast, Saccharomyces cerevisiae. It was observed that the structural change in TNO-6 resulted in reduced cytotoxicity and recombinagenicity (mitotic gene conversion) but increased mutagenic activity compared to the effects of cisplatin at equimolar concentrations. These results indicated that the mechanism through which TNO-6 damages cellular DNA is different from that of cisplatin.

摘要

研究了抗肿瘤药物顺铂及其类似物TNO-6对酿酒酵母二倍体菌株（D7）的细胞毒性、诱变和重组诱变作用。观察到，与等摩尔浓度的顺铂相比，TNO-6的结构变化导致细胞毒性和重组诱变活性（有丝分裂基因转换）降低，但诱变活性增加。这些结果表明，TNO-6损伤细胞DNA的机制与顺铂不同。