非结核分枝杆菌相关性葡萄膜炎与 HIV 阳性患者。

Nontubercular Mycobacteria Associated Uveitis in HIV Positive Patients.

机构信息

Department of Microbiology, Post Graduate Institute Medical Education and Research, Chandigarh, India.

Advanced Eye Centre, Post Graduate Institute Medical Education and Research, Chandigarh, India.

出版信息

Ocul Immunol Inflamm. 2022 Jan 2;30(1):21-28. doi: 10.1080/09273948.2020.1788610. Epub 2020 Aug 19.

DOI:10.1080/09273948.2020.1788610

PMID:32813606

Abstract

PURPOSE

To report clinical features and outcomes of nontuberculous mycobacteria (NTM) presenting as uveitis in HIV positive patients.

MATERIALS AND METHODS

Retrospective study of HIV positive patients who were diagnosed as uveitis due to NTM.

RESULTS

Six eyes of four HIV positive patients with NTM were studied. Average age at presentation was 35.5 years (range 30-38). With specific PCR primers, was detected in three patients (75%) and in one patient (25%). Culture was positive in two cases. Two eyes (33.33%) each had endophthalmitis and necrotizing retinitis like picture, one eye (16.66%) each had chorioretinitis and frosted branch angitis like. Visual acuity improved in two eyes (33.33%), worsened in three eyes (50%), and remained unchanged in one eye (16.6%).

CONCLUSIONS

NTM infection is a unique entity in immunosuppressed with poor visual outcome. PCR forms a useful tool for rapid diagnosis and timely initiation of specific anti-tuberculosis therapy.

摘要

目的

报告 HIV 阳性患者中表现为葡萄膜炎的非结核分枝杆菌（NTM）的临床特征和结果。

材料与方法

对因 NTM 而被诊断为葡萄膜炎的 HIV 阳性患者进行回顾性研究。

结果

研究了 4 名 HIV 阳性患者的 6 只眼，这些患者均患有 NTM 引起的葡萄膜炎。发病时的平均年龄为 35.5 岁（范围 30-38 岁）。使用特定的 PCR 引物，在 3 名患者（75%）中检测到，在 1 名患者（25%）中检测到。2 例培养阳性。2 只眼（33.33%）各有眼内炎和类似坏死性视网膜炎的表现，1 只眼（16.66%）各有脉络膜炎和类似霜枝血管炎的表现。2 只眼（33.33%）的视力有所改善，3 只眼（50%）的视力恶化，1 只眼（16.67%）的视力保持不变。