肥胖导致男性不育的机制。
The Mechanisms Involved in Obesity-Induced Male Infertility.
机构信息
Department of Physiology, Tabriz Faculty of Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Curr Diabetes Rev. 2021;17(3):259-267. doi: 10.2174/1573399816666200819114032.
BACKGROUND
Obesity resulted by imbalance between the intake of energy and energy consumption can lead to growth and metabolic disease development in people. Both in obese men and animal models, several studies indicate that obesity leads to male infertility.
OBJECTIVE
This review has discussed some mechanisms involved in obesity-induced male infertility.
METHODS
Online documents were searched through Science Direct, Pubmed, Scopus, and Google Scholar websites dating from 1959 to recognize studies on obesity, kisspeptin, leptin, and infertility.
RESULTS
Obesity induced elevated inflammatory cytokines and oxidative stress can affect male reproductive functions, including spermatogenesis disorders, reduced male fertility power and hormones involved in the hypothalamus-pituitary-gonadal axis.
CONCLUSION
There is significant evidence that obesity resulted in male infertility. Obesity has a negative effect on male reproductive function via several mechanisms such as inflammation and oxidative stress.
背景
能量摄入与消耗失衡导致的肥胖会引发人体生长和代谢疾病。多项研究表明，肥胖会导致男性不育，肥胖男性和动物模型均存在这种现象。
目的
本文综述了肥胖导致男性不育的一些相关机制。
方法
通过 Science Direct、Pubmed、Scopus 和 Google Scholar 网站检索 1959 年以来关于肥胖、kisspeptin、瘦素和不育的相关文献，识别相关研究。
结果
肥胖可引起炎症细胞因子和氧化应激水平升高，从而影响男性生殖功能，包括精子发生障碍、生育力降低以及下丘脑-垂体-性腺轴相关激素水平降低。
结论
有充分证据表明肥胖可导致男性不育。肥胖通过炎症和氧化应激等多种机制对男性生殖功能产生负面影响。
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