白藜芦醇通过下调肾细胞癌中的 NLRP3 抑制肿瘤进展。
Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma.
机构信息
Department of Microbiology, School of Laboratory Medicine, Tianjin Medical University, Tianjin 300203, China.
Department of Histology and Embryology, School of Medicine, Nankai University, Tianjin 300071, China.
出版信息
J Nutr Biochem. 2020 Nov;85:108489. doi: 10.1016/j.jnutbio.2020.108489. Epub 2020 Aug 20.
Renal cell carcinoma (RCC) is one of the most common urologic malignant tumors. Current chemotherapy is not effective in RCC and results in some side effects. Resveratrol (RSV) has been reported to exert antitumor effects in some cancer cells; however the mechanism is not fully understood. Herein, we aimed to determine the anticancer effect of RSV on RCC and further explore the underlying molecular mechanism in this process. We found that RSV inhibited tumor cells proliferation, migration and invasion and increased apoptosis of RCC either in vivo or in vitro. RSV significantly down-regulated expressions of NLRP3 and its downstream genes. Inhibition of NLRP3 by NLRP3 small interfering RNA mimicked the effects of RSV on RCC cells. These results suggested that RSV could exert antitumor effect by depressing activity of NLRP3, and NLRP3 would be a promising clinical therapeutic strategy for RCC.
肾细胞癌 (RCC) 是最常见的泌尿系统恶性肿瘤之一。目前的化疗对 RCC 无效，并导致一些副作用。白藜芦醇 (RSV) 已被报道在一些癌细胞中发挥抗肿瘤作用，但机制尚不完全清楚。在此，我们旨在确定 RSV 对 RCC 的抗癌作用，并进一步探讨这一过程中的潜在分子机制。我们发现 RSV 抑制肿瘤细胞的增殖、迁移和侵袭，并增加 RCC 的细胞凋亡，无论是在体内还是体外。RSV 显著下调 NLRP3 及其下游基因的表达。NLRP3 小干扰 RNA 的抑制作用模拟了 RSV 对 RCC 细胞的作用。这些结果表明，RSV 可以通过抑制 NLRP3 的活性发挥抗肿瘤作用，NLRP3 可能成为治疗 RCC 的一种有前途的临床治疗策略。
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