Ditscherlein G, Höppchen R, Schneider W, Wassilew G
Institut für Pathologische Anatomie, Humboldt-Universität Berlin.
Z Urol Nephrol. 1988 Jan;81(1):13-8.
To determine the question of the extent of fibrous intimal swelling in chronic transplant vasculopathy, of fibrous interstitial broadening and of tubular atrophy, we performed semi-quantitative histological examinations on 139 biopsy specimens, 70 removed kidney allografts and 35 allografts after autopsy, respectively. A positive correlation was found between vascular and interstitial changes. Morphometric analyses were done in 9 removed transplants and 2 normal kidneys, at which in each case 4 cortical regions including the supplying middle-sized and small arteries are examined. It was shown, that the extent of intimal swelling was variable and in the same sense also the degree of interstitial proliferation. Thus, the correlation as mentioned above is confirmed. Therefore, it is presumed that the extent of chronic transplant vasculopathy with reduction of the blood supply is most important to the formation of interstitial broadening and tubular atrophy. On principle other causes are possible and must be excluded by histological and/or angiographic investigations.
为了确定慢性移植血管病中纤维内膜肿胀的程度、纤维间质增宽的程度以及肾小管萎缩的问题，我们分别对139份活检标本、70个切除的同种异体肾移植以及35个尸检后的同种异体移植进行了半定量组织学检查。发现血管和间质变化之间存在正相关。对9个切除的移植肾和2个正常肾脏进行了形态计量分析，在每种情况下检查包括供应的中、小动脉在内的4个皮质区域。结果表明，内膜肿胀的程度是可变的，间质增殖的程度也是如此。因此，上述相关性得到了证实。因此，据推测，伴有血供减少的慢性移植血管病的程度对间质增宽和肾小管萎缩的形成最为重要。原则上其他原因也是可能的，必须通过组织学和/或血管造影检查予以排除。
