Expression Level and Clinical Significance of NKILA in Human Cancers: A Systematic Review and Meta-Analysis.

BACKGROUND

A number of researches focused on the study of tumors have concluded that the expression level of lncRNA was decreased in different tumors. This is an indication that might influence the start and growth of a cancer. In addition, studies have fatalities and worsening health of cancer patients is associated with a reduced level of .

RESULTS

The results are the collective screening of nine total studies which included 937 cancer patients. The prognosis of the meta-analysis indicated that cancer patients with a higher expression of had an overall longer survival (OS) (HR = 0.808, 95% CI: 0.736, 0.887); with regard to the clinical prognosis, the results indicated that reduced was associated with advanced clinical stage (OR = 0.313, 95% CI: 0.225, 0.434), poor histological grades (OR = 0.833, 95% CI: 0.508, 1.367), positive lymph node metastasis (OR = 0.253, 95% CI: 0.144, 0.444), and additional tumor invasion depth (OR = 0.326, 95% CI: 0.234, 0.454).

MATERIALS AND METHODS

Related research conducted was accessed by searching in PubMed and Web of Science with the keywords. The accessed material was till the 25 of February, 2020. The present quantitative meta-analysis was done using Stata SE12.0. The aim of the meta-analysis was to investigate the relationship between expression level and clinical prognosis.

CONCLUSIONS

In the result of this meta-analysis, decreased expression is typical of different kinds of cancer. Moreover, it can perform as a predictive element of prognosis in varied kinds of cancer. Nonetheless, till now, it is deemed essential to carry out larger-size as well as better designed research works for the confirmation of our findings.