Abizadeh Marzieh, Heysieattalab Soomaayeh, Saeedi Negin, Hosseinmardi Narges, Janahmadi Mahyar, Salari Farhad, Golpayegani Seyed Mehdi, Shojaii Asie
Department of Physiology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neurophysiology Research Center, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Planta Med. 2020 Dec;86(18):1353-1362. doi: 10.1055/a-1229-4436. Epub 2020 Aug 26.
The objective of the current study was to investigate the anti-epileptogenic and anticonvulsant effects of gum, which is used in Iranian traditional medicine for the treatment of seizures. Animals received pentylenetetrazol (IP, 30 mg/kg/48 h) for inducing seizures. Five different seizure stages were evaluated for 20 min and parameters including maximum seizure stage, the latency to the onset of stage 4, stage 4 duration, and seizure duration were measured. (50 and 100 mg/kg) or its vehicle was administered 30 min before or after pentylenetetrazol injection in different groups. In addition, the effective dose of (100 mg/kg) on different seizure stages was compared with the common antiseizure drug phenobarbital. In another set of experiments, we investigated the effective dose of on fully kindled animals in which an interictal electroencephalogram was recorded by superficial electrodes placed on the skull. The results showed that administration, before and after pentylenetetrazol injections, significantly decreased seizure stage, seizure duration, stage 4 duration, and 1/stage 4 latency. The anti-epileptogenic effect of was about 50 to 60% of phenobarbital. In addition, significantly decreased seizure stage, seizure duration, stage 4 duration, and 1/stage 4 latency when administered to fully kindled animals but had no effect on the power of EEG sub-bands. These results indicate that has anti-epileptogenic and anticonvulsant effects in a chemical kindling model of seizures.
本研究的目的是调查一种在伊朗传统医学中用于治疗癫痫发作的口香糖的抗癫痫发生和抗惊厥作用。动物接受戊四氮（腹腔注射，30毫克/千克/48小时）以诱发癫痫发作。对五个不同的癫痫发作阶段进行20分钟的评估，并测量包括最大癫痫发作阶段、第4阶段发作潜伏期、第4阶段持续时间和癫痫发作持续时间等参数。在不同组中，在戊四氮注射前或后30分钟给予（50和100毫克/千克）或其赋形剂。此外，将（100毫克/千克）对不同癫痫发作阶段的有效剂量与常用抗癫痫药物苯巴比妥进行比较。在另一组实验中，我们研究了对完全点燃动物的有效剂量，其中通过放置在颅骨上的表面电极记录发作间期脑电图。结果表明，在戊四氮注射前后给予，显著降低了癫痫发作阶段、癫痫发作持续时间、第4阶段持续时间和1/第4阶段潜伏期。的抗癫痫发生作用约为苯巴比妥的50%至60%。此外，当给予完全点燃动物时，显著降低了癫痫发作阶段、癫痫发作持续时间、第4阶段持续时间和1/第4阶段潜伏期，但对脑电图子带的功率没有影响。这些结果表明，在癫痫发作的化学点燃模型中具有抗癫痫发生和抗惊厥作用。
