Zheng Yongsu, Wei Nian, Wang Jian, Dai Hui, Xu Zucai
Department of Neurology, Affiliated Hospital of Zunyi Medical University, Guizhou, China.
Department of Neurology, Guizhou Aerospace Hospital, Guizhou, China.
J Int Med Res. 2020 Aug;48(8):300060520947914. doi: 10.1177/0300060520947914.
Autoimmune epilepsy (AE) refers to epilepsy mediated by autoantibodies or immune cells, and a large proportion of drug-resistant epilepsy cases are classified as AE. AE lacks standardized management guidelines. At present, little research has been conducted on the effectiveness of surgical treatment of AE. This paper reports a patient whose surgical treatment was ineffective before AE was diagnosed and who improved after immunotherapy. A literature review was conducted to examine the progress of surgical treatment of epilepsy, the relationship of temporal lobe epilepsy to neuronal antibodies, surgical and prognostic factors, research progress on the anti-Hu antibody, and treatment of autoimmune encephalitis to provide a clinical reference.
自身免疫性癫痫（AE）是指由自身抗体或免疫细胞介导的癫痫，很大一部分耐药性癫痫病例被归类为AE。AE缺乏标准化的管理指南。目前，关于AE外科治疗有效性的研究较少。本文报告了1例患者，其在AE诊断之前接受的外科治疗无效，而在免疫治疗后病情改善。进行文献综述以考察癫痫外科治疗的进展、颞叶癫痫与神经元抗体的关系、手术及预后因素、抗Hu抗体的研究进展以及自身免疫性脑炎的治疗，以提供临床参考。
