遵循推荐摄入量的钙与结直肠癌风险的 HEXA 研究。
Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study.
机构信息
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Cancer Research Institute, Seoul National University, Seoul, Korea.
出版信息
Cancer Res Treat. 2021 Jan;53(1):140-147. doi: 10.4143/crt.2020.480. Epub 2020 Aug 25.
PURPOSE
Dietary calcium intake has been suggested to be protective against the development of colorectal cancer. The mean dietary calcium intake of Koreans is 490 mg/day, which is far below the recommended calcium intake of 700-800 mg/day. In this study, we explored the relationship between dietary calcium intake and colorectal cancer development in Koreans with relatively low calcium intake compared with individuals in Western countries.
MATERIALS AND METHODS
The Health Examinees Study, a large-scale genomic community-based prospective cohort study, was designed to identify the general characteristics of major chronic diseases in Koreans. A total of 119,501 participants aged 40-69 years recruited between 2004 and 2013 were included in this analysis. The calcium intake level was categorized using the Dietary Reference Intakes for Koreans (KDRIs). The Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and the corresponding 95% confidence intervals (CIs) for colorectal cancer risk, adjusting for potential confounders.
RESULTS
In the multivariable-adjusted model, compared with the group that consumed less than the recommended amount of calcium, the group that consumed more than the recommended intake of calcium showed a significant reduction in the risk of colorectal cancer in women. (HR, 0.54; 95% CI, 0.31 to 0.95). Among men, however, no significant association was observed between dietary calcium intake and colorectal cancer risk (HR, 0.89; 95% CI, 0.54 to 1.45).
CONCLUSION
Korean women who adhere to the recommended intake of calcium showed a reduced risk of colorectal cancer.
目的
饮食钙的摄入量被认为可以预防结直肠癌的发生。韩国人的平均饮食钙摄入量为 490 毫克/天，远低于推荐的 700-800 毫克/天的钙摄入量。在这项研究中，我们探索了与西方国家相比钙摄入量相对较低的韩国人饮食钙摄入量与结直肠癌发展之间的关系。
材料和方法
健康体检者研究是一项大规模的基于基因组的社区前瞻性队列研究，旨在确定韩国人主要慢性疾病的一般特征。共有 119501 名年龄在 40-69 岁之间的参与者于 2004 年至 2013 年被招募入组进行分析。钙摄入量水平是根据韩国的膳食参考摄入量（KDRIs）进行分类的。使用 Cox 比例风险回归模型来估计结直肠癌风险的风险比（HR）和相应的 95%置信区间（CI），并调整了潜在的混杂因素。
结果
在多变量调整模型中，与摄入低于推荐量钙的组相比，摄入高于推荐量钙的组女性结直肠癌风险显著降低。（HR，0.54；95%CI，0.31 至 0.95）。然而，对于男性，饮食钙摄入量与结直肠癌风险之间没有显著关联（HR，0.89；95%CI，0.54 至 1.45）。
结论
坚持推荐钙摄入量的韩国女性结直肠癌风险降低。
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