Bull Hosp Jt Dis (2013). 2020 Sep;78(3):169-172.
Many orthopedic surgeons decline to perform total knee arthroplasty on patients for whom the use of blood components are not an option due to the perceived risk of acute blood loss-related anemia and subsequent mortality. While tourniquets were previously believed to reduce blood loss during total knee arthroplasty, recent studies suggest similar volumes of blood loss and increased risk of other complications when performed with using a tourniquet. Antifibrinolytics are a safe alternative to tourniquets in reducing blood loss in total knee arthroplasty.
The current study analyzed the use of antifibrinolytics in Jehovah's Witness patients for total knee arthroplasty performed without a tourniquet. Hemoglobin values were measured on 64 patients preoperatively, 1 hour postoperative, and 72 hours postoperatively. Relative change in hemoglobin was analyzed by the t-test.
The average drop in hemoglobin from preoperatively to postoperatively was 1.61 g/dl (p < 0.001). At a mean follow-up of 20 months (range: 1 to 73 months) there was one incidence of a deep vein thrombosis, one deep infection requiring a two-stage revision, and three patients requiring manipulation for stiffness. There were no pulmonary embolisms (PEs) and a 0% mortality rate.
Total knee arthroplasty in Jehovah's Witness patients can be done safely and efficiently using antifibrinolytic therapy without a tourniquet.
许多骨科医生因为担心急性失血相关贫血和随后的死亡率,拒绝为不能使用血液成分的患者进行全膝关节置换术。虽然以前认为止血带可以减少全膝关节置换术中的失血,但最近的研究表明,使用止血带时,失血量相似,但其他并发症的风险增加。抗纤维蛋白溶解剂是减少全膝关节置换术中失血的安全替代方法,而不使用止血带。
本研究分析了在不使用止血带的情况下,接受全膝关节置换术的耶和华见证人患者使用抗纤维蛋白溶解剂的情况。64 例患者术前、术后 1 小时和术后 72 小时测量血红蛋白值。用 t 检验分析血红蛋白的相对变化。
血红蛋白从术前到术后平均下降 1.61g/dl(p<0.001)。平均随访 20 个月(范围:1 至 73 个月),发生深静脉血栓 1 例,需要两期翻修的深部感染 1 例,需要手法治疗僵硬的患者 3 例。无肺栓塞(PE)和 0%死亡率。
在不使用止血带的情况下,使用抗纤维蛋白溶解剂治疗,耶和华见证人患者的全膝关节置换术可以安全有效地进行。