放射性核素心肌灌注显像时瑞加德松给药与 QT 间期延长。
Regadenoson administration and QT interval prolongation during pharmacological radionuclide myocardial perfusion imaging.
机构信息
BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA.
Mount Sinai St. Luke's - Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, USA.
出版信息
Indian Heart J. 2020 Jul-Aug;72(4):296-298. doi: 10.1016/j.ihj.2020.06.015. Epub 2020 Jul 3.
The objective of our study is to assess change in QTc interval with Regadenoson administration during myocardial perfusion imaging (MPI). We conducted a retrospective, observational analysis of 1497 consecutive patients who underwent pharmacological radionuclide MPI. On multivariate logistic regression analyses, there was no statistical significance of QTc prolongation when adjusted for ischemia/fixed perfusion defect on MPI and QT prolonging medications being taken prior to stress testing. However, a positive stress ECG after Regadenoson injection had a statistical significance (p value 0.0004). Regadenoson is a safe drug for use in MPI with little, if any, side effects of major clinical significance.
我们的研究目的是评估在心肌灌注成像（MPI）期间使用雷卡地诺生时 QTc 间期的变化。我们对 1497 例连续接受放射性核素药物 MPI 的患者进行了回顾性观察性分析。多变量逻辑回归分析显示，当根据 MPI 上的缺血/固定灌注缺损以及在应激试验前服用的延长 QT 药物进行调整时，QTc 延长无统计学意义。然而，雷卡地诺生注射后阳性应激心电图有统计学意义（p 值 0.0004）。雷卡地诺生是一种用于 MPI 的安全药物，几乎没有任何具有重大临床意义的主要副作用。
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