用于鉴定子宫收缩新调节因子的药物发现策略。
Drug discovery strategies for the identification of novel regulators of uterine contractility.
作者信息
Siricilla Shajila, Iwueke Chisom C, Herington Jennifer L
机构信息
Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Curr Opin Physiol. 2020 Feb;13:71-86. doi: 10.1016/j.cophys.2019.10.012. Epub 2019 Oct 23.
Abstract
Preterm birth and postpartum hemorrhage are the leading causes of neonatal and maternal morbidities worldwide, respectively. Current clinically utilized tocolytics and uterotonics to manage these obstetric conditions are limited due to their off-target effects and/or lack of efficacy. Thus, an ideal tocolytic or uterotonic would be uterine-selective with rapid onset and long-duration efficacy. Here, we discuss strategies for the discovery of new therapeutic targets and compounds that regulate uterine contractility with the aforementioned properties.
摘要
早产和产后出血分别是全球新生儿和孕产妇发病的主要原因。目前临床上用于治疗这些产科疾病的宫缩抑制剂和宫缩剂由于其脱靶效应和/或疗效不足而受到限制。因此，理想的宫缩抑制剂或宫缩剂应具有子宫选择性，起效迅速且疗效持久。在此，我们讨论发现具有上述特性的调节子宫收缩力的新治疗靶点和化合物的策略。
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